Low serum levels of bone turnover markers are associated with the presence and severity of diabetic retinopathy in patients with type 2 diabetes mellitus.

Journal of Diabetes
Yaxin AnDong Zhao

Abstract

Accumulating evidence demonstrates an association of type 2 diabetes mellitus (T2DM) and its microvascular complications with increased fracture risk. In this study, we aimed to evaluate the relationships between serum concentrations of bone turnover markers and the presence and/or severity of diabetic retinopathy (DR) among patients with T2DM. A total of 285 patients with T2DM comprising 168 patients without DR and 117 patients with DR were enrolled in the cross-sectional study. In the latter group, patients were further divided into patients of mild and severe DR stages. The biochemical parameters and bone turnover markers were determined in all participants. This study found that serum levels of procollagen type 1 N-terminal propeptide (P1NP), a bone formation marker, and the bone resorption marker serum β-cross-linked C-telopeptide of type I collagen (β-CTX) were more decreased in diabetic patients with DR than in those without DR, with differences remaining significant (P < .05) in multivariate linear regression models after adjustments for multiple confounding factors. Osteocalcin and β-CTX levels were further reduced along with the severity of DR among participants with DR. Moreover, multivariate logistic regression anal...Continue Reading

References

Mar 15, 1995·Annals of Internal Medicine·P L van DaeleH A Pols
Mar 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P GarneroP D Delmas
Jul 2, 1999·Diabetes Care·J T TuominenT Rönnemaa
Jun 26, 2001·Diabetes Care·R Q IversUNKNOWN Blue Mountains Eye Study
Jun 7, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Owe LöfmanLasse Larsson
Jun 1, 2006·The Journal of Clinical Endocrinology and Metabolism·Harald DobnigAstrid Fahrleitner-Pammer
Aug 19, 2007·Cell·Na Kyung LeeGerard Karsenty
Aug 23, 2007·JAMA : the Journal of the American Medical Association·Quresh MohamedTien Y Wong
Dec 4, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Masahiro YamamotoToshitsugu Sugimoto
Dec 18, 2008·The Journal of Clinical Endocrinology and Metabolism·Anastassios G PittasBess Dawson-Hughes
Jan 27, 2009·Ophthalmology·Feng Hua WangTien Yin Wong
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Nov 10, 2009·Diabetes Research and Clinical Practice·J E ShawP Z Zimmet
May 28, 2010·Diabetes Care·Woon-Puay KohMimi C Yu
Jun 29, 2010·Lancet·Ning CheungTien Yin Wong
Jun 3, 2011·JAMA : the Journal of the American Medical Association·Ann V SchwartzUNKNOWN Health, Aging, and Body Composition (Health ABC) Research Group
Feb 4, 2012·Diabetes Care·Joanne W Y YauUNKNOWN Meta-Analysis for Eye Disease (META-EYE) Study Group
Jun 6, 2012·Nature Reviews. Rheumatology·Kim Naylor, Richard Eastell
Jun 29, 2012·The Journal of Clinical Endocrinology and Metabolism·J S ManavalanM R Rubin
Jan 24, 2013·Diabetes Care·Volha V ZhukouskayaIacopo Chiodini
Mar 1, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E S SirisN B Watts
Aug 21, 2014·International Journal of Endocrinology·Nicola NapoliSol Epstein
Oct 25, 2014·The Journal of Clinical Endocrinology and Metabolism·Yan XuanGuang Ning
Feb 28, 2015·Bone·Jakob Starup-Linde, Peter Vestergaard
Nov 6, 2015·European Journal of Endocrinology·Vikram Vinod ShanbhogueKim Brixen
Feb 18, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Y LimM-I Kang
Nov 9, 2016·Journal of Diabetes and Metabolic Disorders·Zhila MaghbooliArash Hossein-Nezhad
Aug 11, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P JiaH Tang
Apr 7, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Cristian TebéDaniel Prieto-Alhambra
Jul 4, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L T Ho-PhamT V Nguyen
Feb 18, 2019·Endocrine Connections·Ann-Kristin PickeMartina Rauner
Mar 31, 2020·Acta Diabetologica·Paolo LanzettaUNKNOWN Vision Academy

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Citations

May 15, 2021·Current Opinion in Endocrinology, Diabetes, and Obesity·Nourah AlmutlaqLinda A DiMeglio
Jul 5, 2021·BMC Cardiovascular Disorders·Jennifer M T A MeessenUNKNOWN PREDICTOR Investigators

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