Low Serum Levels of DKK2 Predict Incident Low-Impact Fracture in Older Women

JBMR Plus
Ana M RodriguesHelena Canhão

Abstract

There are currently no robust noninvasive markers of fragility fractures. Secreted frizzled related protein-1 (sFRP-1), dickkopf-related protein 1 (DKK1) and DKK2, and sclerostin (SOST) inhibit Wnt signaling and interfere with osteoblast-mediated bone formation. We evaluated associations of serum levels of sFRP-1, DKK1, DKK2, and SOST with incident low-impact fracture and BMD in 828 women aged ≥65 years from EpiDoC, a longitudinal population-based cohort. A structured questionnaire during a baseline clinical appointment assessed prevalent fragility fractures and clinical risk factors (CRFs) for fracture. Blood was collected to measure serum levels of bone turnover markers and Wnt regulators. Lumbar spine and hip BMD were determined by DXA scanning. Follow-up assessment was performed through a phone interview; incident fragility fracture was defined by any new self-reported low-impact fracture. Multivariate Cox proportional hazard models were used to analyze fracture risk adjusted for CRFs and BMD. During a mean follow-up of 2.3 ± 1.0 years, 62 low-impact fractures were sustained in 58 women. A low serum DKK2 level (per 1 SD decrease) was associated with a 1.5-fold increase in fracture risk independently of BMD and CRFs. Women i...Continue Reading

References

Jul 15, 1994·American Journal of Epidemiology·G SchulgenM Schumacher
Oct 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P GarneroP D Delmas
Jan 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L J MeltonE S Siris
Aug 18, 1997·The American Journal of Medicine·O Johnell
Feb 7, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A C LookerS P Heyse
Sep 3, 1999·American Journal of Epidemiology·K HonkanenS Saarikoski
May 29, 2000·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A A IsmailA J Silman
May 15, 2002·Journal of Clinical Epidemiology·Rebecca Q IversAnthony J Peduto
Jun 7, 2002·Lancet·Steven R Cummings, L Joseph Melton
Jul 12, 2002·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·O JohnellJ A Kanis
Sep 9, 2005·Journal of Cellular Biochemistry·Peter V N BodineBarry S Komm
Mar 17, 2007·Psychology, Health & Medicine·J Pais-RibeiroM Baltar
Dec 22, 2007·Bone·P RoschgerK Klaushofer
Feb 23, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisE McCloskey
Aug 30, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisUNKNOWN National Osteoporosis Guideline Group
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Jul 15, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Wei YaoNancy E Lane
Oct 17, 2009·Clinical Endocrinology·Athanasios D AnastasilakisEvangelos Terpos
Aug 20, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ulrike I MödderSundeep Khosla
Oct 13, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Joseph S ButlerJohn M O'Byrne
Dec 25, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S VasikaranUNKNOWN IOF-IFCC Bone Marker Standards Working Group
Feb 10, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S A PolyzosE Terpos
Feb 12, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Thomas F ChanDaniel Lajeunesse
Aug 4, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mohammed-Salleh M ArdawiMohammed H Qari
Nov 15, 2011·Gene·David G MonroeJennifer J Westendorf
Apr 3, 2012·The Journal of Clinical Endocrinology and Metabolism·Aarthi ArasuUNKNOWN Study of Osteoporotic Fractures Research Group
Apr 25, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P GarneroR D Chapurlat
May 17, 2012·Science Signaling·Ju BaoDianqing Wu
Jun 6, 2012·Nature Reviews. Rheumatology·Kim Naylor, Richard Eastell
Jul 28, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mohammed-Salleh M ArdawiShaker A Mousa
Apr 18, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Katrine Hass RubinKim Brixen
Jul 19, 2013·The Journal of Clinical Endocrinology and Metabolism·Claire DurosierRené Rizzoli
Jan 9, 2014·Annals of Clinical Biochemistry·Thinn Thinn Hlaing, Juliet E Compston
Mar 5, 2014·Calcified Tissue International·Helena JohanssonUNKNOWN IFCC-IOF Joint Working Group on Standardisation of Biochemical Markers of Bone Turnover
May 2, 2014·Journal of the American Geriatrics Society·Karin AmreinAstrid Fahrleitner-Pammer
Oct 17, 2014·The Journal of Clinical Endocrinology and Metabolism·S A Paul ChubbBu B Yeap
Nov 1, 2016·The New England Journal of Medicine·Felicia CosmanAndreas Grauer
Nov 27, 2016·Cellular and Molecular Life Sciences : CMLS·Courtney M Karner, Fanxin Long

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Methods Mentioned

BETA
ELISA

Software Mentioned

Stata IC
SOST

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