Low Serum Pancreatic Amylase and Lipase Values Are Simple and Useful Predictors to Diagnose Chronic Pancreatitis

Gut and Liver
Hyoung-Chul OhGlen A Lehman

Abstract

This study aimed to evaluate the diagnostic role of low serum amylase and lipase values in the detection of chronic pancreatitis. Patients underwent endoscopic retrograde cholangiopancreatography and were diagnosed with non-calcific chronic pancreatitis (NCCP; n=99) and calcific chronic pancreatitis (CCP; n=112). Patient serum amylase and lipase values were compared with those of healthy controls (H; n=170). The median serum amylase (normal range, 19 to 86 U/L) and lipase values (7 to 59 U/L) (P₂₅-P₇₅) were 47.0 (39.8 to 55.3) and 25.0 (18.0 to 35.0) for H, 34.0 (24.5 to 49.0) and 19.0 (9.0 to 30.0) for NCCP, and 30.0 (20.0 to 40.8) and 10.0 (3.0 to 19.0) for CCP, respectively. The cutoff values with the highest diagnostic accuracy for discriminating NCCP from H were 40 U/L for amylase and 20 U/L for lipase, respectively, and for CCP from H were 38 U/L for amylase and 15 U/L for lipase, respectively. For the diagnosis of NCCP with a criterion of serum amylase <40 and lipase <20 U/L, the sensitivity, specificity, positive predictive value, and negative predictive values were 37.4%, 88.8%, 66.1%, and 70.9%, respectively. Serum amylase and/or lipase levels below the normal serum range are highly specific for chronic pancreatitis p...Continue Reading

References

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Citations

Sep 1, 2019·Current Diabetes Reports·Federica VecchioAlessandra Petrelli
Aug 1, 2018·Expert Review of Endocrinology & Metabolism·Patrick J D ElderThomas M Barber
Aug 21, 2019·United European Gastroenterology Journal·Søren Schou OlesenAsbjørn Mohr Drewes
Mar 7, 2019·The Korean Journal of Internal Medicine·Chang-Il KwonGlen A Lehman
Feb 17, 2021·BMJ Open Diabetes Research & Care·Nicoletta DozioEmanuele Bosi
Nov 20, 2021·Science Advances·Ourania ChatzidoukakiGeorge A Garinis

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BETA
X-ray
surgical resection

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SPSS

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