Low serum sclerostin levels in newborns with vitamin D deficiency

Journal of Pediatric Endocrinology & Metabolism : JPEM
Ozgur PirgonBumin Dundar

Abstract

Sclerostin is a glycoprotein produced by osteocytes that is being evaluated as a potential clinical marker of bone turnover. The aim of this study was to investigate the association between neonatal vitamin D status and levels of circulating sclerostin. Forty newborns were recruited for the study. Vitamin D deficiency was defined as a serum 25-hydroxyvitamin D3 [25(OH)D] concentration <20 ng/mL and the newborns were divided into two groups as vitamin D deficient and vitamin D sufficient groups. Calcium, phosphate, alkaline phosphatase and sclerostin were measured at birth. Newborns with vitamin D deficiency had markedly lower 25(OH)D levels than vitamin D sufficient newborns (8.5±4.4 ng/mL vs. 35.3±10.6 ng/mL, p<0.001). Vitamin D deficient infants also had significantly lower serum sclerostin levels (188.4±21.9 vs. 282.3±30.4 pg/mL; p: 0.026) than vitamin D sufficient newborns at birth. However, we did not detect a significant linear association between neonatal sclerostin and maternal/neonatal 25(OH)D levels. Our data also demonstrated that vitamin D deficient newborns exhibited lower sclerostin levels than vitamin D sufficient newborns. The low sclerostin level might serve as a marker of decreased osteocyte activity in newbor...Continue Reading

References

May 11, 2005·The American Journal of Clinical Nutrition·Alok SachanVijayalakshmi Bhatia
Dec 15, 2005·The Journal of Clinical Endocrinology and Metabolism·Ruth MorleyJohn D Wark
Feb 8, 2007·The American Journal of Clinical Nutrition·Steven A Abrams
Feb 14, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Xiaodong LiChris Paszty
Jun 25, 2008·Clinical Endocrinology·Lucy BowyerMaria E Craig
Aug 12, 2008·The American Journal of Clinical Nutrition·Frank R Greer
May 8, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Chuwen LinLin He
Jul 15, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ina KramerMichaela Kneissel
Oct 19, 2010·The Journal of Biological Chemistry·Carola KrausePeter ten Dijke
Sep 23, 2011·The Journal of Clinical Endocrinology and Metabolism·Aline G CostaJohn P Bilezikian
Oct 1, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Bridget E YoungKimberly O O'Brien
Dec 14, 2011·Paediatric and Perinatal Epidemiology·Oya HaliciogluEbru S Gulec
Aug 14, 2012·Proceedings of the National Academy of Sciences of the United States of America·Nicole M ColletteGabriela G Loots
Sep 4, 2012·Bone·Charles A O'BrienHiroshi Takayanagi
Mar 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Zachary C RyanRajiv Kumar
Jul 19, 2013·The Journal of Clinical Endocrinology and Metabolism·Claire DurosierRené Rizzoli
Feb 4, 2014·European Journal of Endocrinology·Bess Dawson-HughesNancy J Palermo
Feb 12, 2014·The Journal of Clinical Endocrinology and Metabolism·Telma PalomoFrank Rauch
Jun 4, 2014·European Journal of Endocrinology·Antonino CatalanoAntonino Di Benedetto

❮ Previous
Next ❯

Citations

Mar 24, 2016·Journal of Pediatric Endocrinology & Metabolism : JPEM·Wieland KiessJürgen Kratzsch

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research
Gonca SandalHalil Ibrahim Bayram
© 2021 Meta ULC. All rights reserved