PMID: 3767414Sep 1, 1986Paper

Low serum thyroxine concentrations and neural maturation in preterm infants

Archives of Disease in Childhood
L S de VriesV Dubowitz

Abstract

The effect of hypothyroxinaemia on postnatal progression of the motor nerve conduction velocity was studied in 33 very low birthweight infants. Serum concentrations of thyroid stimulating hormone, triiodothyronine, and thyroxine were determined at birth and at ages 3, 7, and 21 days. Nerve conduction velocity was measured in the first week of life, on day 21, and at 40 weeks' postmenstrual age. Seven infants maintained their thyroxine concentration above 60 nmol/l (4.67 micrograms/100 ml) throughout the study. Three of these infants needed mechanical ventilation and one had an intraventricular haemorrhage. Twenty six infants developed hypothyroxinaemia (thyroxine less than 60 nmol/l). The nerve conduction velocity was delayed in 13 infants, two on day 21 and 11 at 40 weeks' postmenstrual age. The delay was equivalent to 1.9-4.4 weeks. All these infants belonged to the group with depressed thyroxine concentrations. The delay in progression in nerve conduction velocity was associated with prolonged hypothyroxinaemia, especially in those infants who also required ventilation. Further studies are in progress to study the effect of thyroid hormone on the nerve conduction velocity in preterm infants.

References

Jun 1, 1978·The Journal of Pediatrics·S UhrmannR Utiger
Dec 1, 1971·Archives of Disease in Childhood·A Moosa, V Dubowitz
Feb 1, 1973·Journal of the Neurological Sciences·N H Bass, E Young
Jun 1, 1972·Developmental Medicine and Child Neurology·A Moosa, V Dubowitz
Jul 1, 1970·The Journal of Pediatrics·L M DubowitzC Goldberg
Sep 1, 1984·The Journal of Pediatrics·F DelangeA M Ermans
Jun 1, 1982·Archives of Disease in Childhood·M I LeveneR F Lamont
Feb 1, 1981·European Journal of Pediatrics·W SchönbergerW Gempp
May 1, 1981·The Journal of Pediatrics·A H KleinD A Fisher

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Citations

Mar 22, 1997·Proceedings. Biological Sciences·O Potthoff, I D Dietzel
Jul 1, 1992·Archives of Disease in Childhood·W J MeijerJ L van den Brande
Nov 1, 1994·Archives of Disease in Childhood. Fetal and Neonatal Edition·S AresG Morreale de Escobar
Feb 11, 2005·Biology of the Neonate·Camilia R MartinUNKNOWN Developmental Epidemiology Network
Jul 1, 1997·Pediatric Research·C VanholeF de Zegher
Jan 10, 2006·Journal of Pediatric Endocrinology & Metabolism : JPEM·Susana AresGabriela Morreale de Escobar
Feb 9, 2012·Journal of Pediatric Endocrinology & Metabolism : JPEM·Susana AresGabriella Morreale de Escobar
Mar 1, 1996·European Journal of Pediatrics·R P RoomanK J Van Acker
Aug 22, 2000·Archives of Disease in Childhood. Fetal and Neonatal Edition·J RogahnL Amegavie
Nov 15, 2008·Seminars in Perinatology·Susana AresGabriella Morreale de Escobar
Nov 15, 2008·Seminars in Perinatology·Joanne Rovet, Nevena Simic
Mar 1, 1988·Early Human Development·M MercadoH Gold
Jan 10, 2002·Seminars in Perinatology·J H KokA G van Wassenaer
Feb 21, 1998·The Journal of Pediatrics·B J SmitB W Ongerboer de Visser
Jul 1, 1987·Clinical Pediatrics·M MercadoH Gold
Apr 11, 2018·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·S LoriC Dani
May 7, 2004·Journal of Perinatology : Official Journal of the California Perinatal Association·Susan M Scott, Daniel F Cimino
Feb 8, 2013·Endocrinology·Ariann CrudoStephen G Matthews
Oct 20, 2015·The Journal of Clinical Endocrinology and Metabolism·Jonneke J HollandersUNKNOWN Dutch POPS-19 Collaborative Study Group
Mar 23, 1999·Muscle & Nerve·B J SmitB W Ongerboer de Visser
Feb 13, 2003·The Medical Journal of Australia·Ciara M McDonnellMargaret R Zacharin

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