Low serum uric acid concentration in Parkinson's disease in southern Spain

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
S JesúsP Mir

Abstract

Uric acid (UA) is thought to have an antioxidant effect on the central nervous system and may also prevent cerebral damage induced by oxidative stress. Our study aimed to investigate whether patients with Parkinson's disease (PD) had lower serum UA concentrations than controls and whether UA concentration was related to clinical parameters of the disease. We included 161 patients with PD and 178 controls from southern Spain. UA concentration was compared between these two groups. Clinical parameters including severity of the disease were related to serum UA. Patients with PD showed statistically significant lower serum UA concentrations than controls. Serum UA concentration was lower in patients with PD in severe stages (4 and 5) than in those in moderate stage (2) according to the modified Hoehn and Yahr scale. Other clinical parameters were not related to serum UA concentration, except for levodopa equivalent daily dose that was associated with lower serum UA concentration in men. Our study produced consistent findings that UA might have a protective effect against PD and could influence its clinical progression.

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Citations

Nov 28, 2015·Acta neurologica Belgica·Jia LiuFu-Hua Peng
Jan 27, 2016·Journal of Neurochemistry·Edwin K JacksonPatrick M Kochanek
Aug 12, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M MocciaM T Pellecchia
Jan 5, 2020·Nature Reviews. Neurology·Sara MeoniElena Moro
May 29, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Isabel González-AramburuJon Infante
Nov 14, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A H V Schapira
Jan 6, 2017·Journal of Neurology·Marina PicilloMaria Teresa Pellecchia
Nov 24, 2016·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Lijun WangQi Wan
Jul 22, 2018·Frontiers in Molecular Neuroscience·Zexu WeiYong Cheng
Mar 9, 2021·Journal of Parkinson's Disease·Anastasia BougeaLeonidas Stefanis
Aug 11, 2020·Journal of Parkinson's Disease·Yasemin G HasimogluEric A Macklin

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