Low serum vitamin D levels are not associated with increased postoperative pain and opioid requirements: a historical cohort study

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
Somnath BoseAlparslan Turan

Abstract

Vitamin D deficiency has been associated with chronic non-specific musculoskeletal pain syndromes; however, studies are lacking with respect to its relationship with postoperative pain. We tested the hypothesis that a lower preoperative vitamin D level is associated with increased postoperative pain and/or opioid consumption in morbidly obese patients who had laparoscopic bariatric surgery. Data from 185 patients who underwent laparoscopic bariatric surgery at the Cleveland Clinic from 2005-2009 and had a vitamin D level checked within three months of their surgery were included in the analysis. We assessed the relationship between vitamin D levels and the time-weighted average (TWA) of pain scores and total opioid consumption using multivariable regression models adjusted for potential confounders. As a secondary analysis, we compared the TWA of pain scores and opioid consumption between patients who were vitamin D deficient (≤ 20 ng·mL(-1)) and those who were not (vitamin D > 20 ng·mL(-1)). The mean (SD) TWA pain score was 3.8 (1.5) and the median interquartile range [IQR] total opioid consumption (morphine equivalent) was 15.6 [18.2] mg during the first 72 hr postoperatively. The median [IQR] vitamin D concentration was 21.8...Continue Reading

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