Low skeletal muscle mass in stented esophageal cancer predicts poor survival: A retrospective observational study

Thoracic Cancer
Tommi JärvinenJari Räsänen

Abstract

In esophageal cancer, nutritional challenges are extremely common. Malignant obstruction resulting from esophageal cancer (EC) is often treated by the insertion of expandable stents, but little is known as to the role and evolution of sarcopenia in this patient population. The aim of this article was to determine the effects of body mass parameters on survival of advanced EC patients who received a stent for palliation of malignant obstruction. This was a retrospective observational study of 238 EC patients who had a stent inserted for palliation of malignant obstruction between 2005 and 2013. Skeletal muscle mass was calculated from abdominal computed tomography scans, and the patients were divided into sarcopenic and non-sarcopenic groups. A follow-up computed tomography scan was available in 118 patients. The primary outcome was survival, and complication rates and the need for an alternative enteral feeding route were secondary outcomes. Sarcopenia occurred in 199 (85%) patients. Median survival was 146 (range: 76-226) days in the sarcopenia group and 152 (range: 71-249) days in the non-sarcopenic group (P = 0.61). Complication rates between the groups were not significantly different (P = 0.85). In Cox regression analysis,...Continue Reading

References

May 9, 2000·Journal of the American College of Surgeons·J M DalyA M Fremgen
Jun 10, 2006·The American Journal of Clinical Nutrition·Kenneth C FearonUNKNOWN Cancer Cachexia Study Group
Dec 22, 2006·American Journal of Epidemiology·Eric Vittinghoff, Charles E McCulloch
Mar 24, 2009·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M BurstowM A Memon
Apr 9, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Carla M M PradoMichael B Sawyer
Jan 22, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S AntounM B Sawyer
Mar 6, 2010·Cancer Chemotherapy and Pharmacology·Carla M M PradoMichael B Sawyer
Apr 16, 2010·Age and Ageing·Alfonso J Cruz-JentoftUNKNOWN European Working Group on Sarcopenia in Older People
Aug 21, 2010·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Courtney J BalentineDavid H Berger
Aug 25, 2010·Annual Review of Medicine·Shontelle DodsonMitchell S Steiner
Feb 8, 2011·The Lancet Oncology·Kenneth FearonVickie E Baracos
Dec 5, 2012·Nature Reviews. Clinical Oncology·Kenneth FearonVickie Baracos
Jan 29, 2013·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·K H SheetzA C Chang
Feb 25, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D BlumUNKNOWN Euro-Impact
Dec 17, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·B H L TanJ A Catton
Jan 23, 2015·PloS One·Hiroshi FukushimaFumitaka Koga
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal

❮ Previous
Next ❯

Citations

Jul 5, 2021·Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne·Carmen HaiducuGheorghe Andrei Dan
Jan 26, 2022·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Fei ChenBin Ma

❮ Previous
Next ❯

Software Mentioned

R Project R Core Team
R Foundation for Statistical
OsirIX

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.