Low skeletal muscle mass is associated with low aerobic capacity and increased mortality risk in patients with coronary heart disease - a CARE CR study

Clinical Physiology and Functional Imaging
Simon NicholsLee Ingle

Abstract

In patients with chronic heart failure, there is a positive linear relationship between skeletal muscle mass (SMM) and peak oxygen consumption ( V ˙ O2peak ); an independent predictor of all-cause mortality. We investigated the association between SMM and V ˙ O2peak in patients with coronary heart disease (CHD) without a diagnosis of heart failure. Male patients with CHD underwent maximal cardiopulmonary exercise testing and dual X-ray absorptiometry assessment. V ˙ O2peak, the ventilatory anaerobic threshold and peak oxygen pulse were calculated. SMM was expressed as appendicular lean mass (lean mass in both arms and legs) and reported as skeletal muscle index (SMI; kg m-2 ), and as a proportion of total body mass (appendicular skeletal mass [ASM%]). Low SMM was defined as a SMI <7·26 kg m-2 , or ASM% <25·72%. Five-year all-cause mortality risk was calculated using the Calibre 5-year all-cause mortality risk score. Sixty patients were assessed. Thirteen (21·7%) had low SMM. SMI and ASM% correlated positively with V ˙ O2peak (r = 0·431 and 0·473, respectively; P<0·001 for both). SMI and ASM% predicted 16·3% and 12·9% of the variance in V ˙ O2peak , respectively. SMI correlated most closely with peak oxygen p...Continue Reading

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Citations

Jan 18, 2020·Nutrients·Francesco CurcioPasquale Abete
Jun 11, 2020·Medicine and Science in Sports and Exercise·Samuel G WittekindClifford Chin
Jan 19, 2021·Journal of Intellectual Disability Research : JIDR·V D Y BeckT I M Hilgenkamp
Apr 17, 2021·Biochemical and Biophysical Research Communications·Tae-Yeon KimKwang-Ho Lee
May 7, 2021·American Heart Journal·Aayushi JoshiJonathan Afilalo
Jan 5, 2021·Medicine and Science in Sports and Exercise·Changhyun LimStuart M Phillips

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Methods Mentioned

BETA
coronary artery bypass
X‐ray
blood draw

Software Mentioned

Lunar iDXA
CALIBER
Calibre
SPSS

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