Low sodium status in cystic fibrosis-as assessed by calculating fractional Na(+) excretion-is associated with decreased growth parameters

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
Christiane KnepperP Heinz-Erian

Abstract

In CF infants, normonatremic Na(+) depletion (NNaD), identified by fractional Na(+) excretion (FENa) values <0.5%, was recently linked to impaired growth. Our paper investigates the relationship between FENa and growth in CF children >2years. FENa values were calculated in 35 CF and 24 control children, and tested for correlations with z-scores for weight, height and BMI. All CF children and controls had normal plasma Na(+) concentrations. A total of 25 of 35 (71.4%) CF patients had decreased FENa values <0.5% (group I). FENa results of 10 CF patients (group II) and 23/24 controls (group III) were normal. In Na(+)-depleted CF children, compared to normal controls, mean z-scores for weight (-0.18±0.87 vs +1.03±0.57, p<0.001), height (-0.06±0.89 vs +0.53±0.72, p=0.009) and BMI (-0.22±0.87 vs +1.00±1.06, p<0.001) were significantly reduced. Also, we found positive correlations between FENa values and z-scores for weight (r=0.521), height (r=0.292) and BMI (r=0.468), respectively. NNaD may contribute to poor growth in CF.

Citations

May 24, 2018·Neonatal Network : NN·Paulina A Saravia, Cheryl Riley
Oct 1, 2019·Current Opinion in Pulmonary Medicine·Mordechai Slae, Michael Wilschanski
Apr 4, 2021·International Journal of Molecular Sciences·Birgitta Strandvik
Jul 19, 2020·Journal of the Academy of Nutrition and Dietetics·Dimitri DeclercqStephanie Van Biervliet

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