PMID: 8971794Nov 22, 1996Paper

Low stringency hybridization study of the dopamine D4 receptor revealed D4-like mRNA distribution of the orphan seven-transmembrane receptor, APJ, in human brain

Neuroscience Letters
M MatsumotoT Yamaguchi

Abstract

We recently reported that the density of mRNA for the dopamine D4 receptor was extremely low in human cerebral cortex but unexpectedly higher in the corpus callosum and spinal cord both of which contain substantial white-matter area. Under low stringency conditions, Northern blot analysis using the D4 probe detected cross-hybridized mRNAs having a similar distributional profile to the D4 mRNA in human brain regions, suggesting the mRNA distributional profile is not peculiar to the D4 receptor. Homology screening revealed one of the mRNAs to be an orphan seven-transmembrane receptor, APJ, abundantly expressed in the corpus callosum and spinal cord. In porcine spinal cord the APJ mRNA was detected at a higher level in white-matter rather than in gray-matter area. These data suggest that a group of seven-transmembrane receptors, including the D4 and APJ receptor, is preferentially expressed in the white-matter area probably in non-neuronal glial cells.

References

Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·G F JirikowskiF E Bloom
Apr 1, 1994·Brain Research. Molecular Brain Research·T SkutellaG F Jirikowski
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·C Matute, R Miledi
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·C MatuteR Miledi

❮ Previous
Next ❯

Citations

Jun 2, 2000·Biochemical and Biophysical Research Communications·M MatsumotoK Furuichi
May 24, 2005·Pharmacology & Therapeutics·Matthias J Kleinz, Anthony P Davenport
Jan 3, 2001·European Journal of Pharmacology·R P EbsteinR H Belmaker
Apr 2, 2003·Virology·Naiming ZhouRoger J Pomerantz
Sep 11, 1999·Trends in Neurosciences·R J Miller, O Meucci
Aug 2, 2002·Neuroscience·A ReauxC Llorens-Cortes
Jul 14, 2010·American Journal of Respiratory and Critical Care Medicine·Yvonne P de VisserGerry T M Wagenaar
Aug 15, 2013·The Journal of Endocrinology·Anne-Marie O'CarrollGeorge R Pope
May 7, 2008·Expert Review of Neurotherapeutics·Patrick B Wood
Jun 26, 2012·Developmental Cognitive Neuroscience·Susanne GilsbachKerstin Konrad
Jun 1, 2012·Expert Opinion on Drug Discovery·Christopher J Charles
May 6, 2014·Expert Review of Cardiovascular Therapy·Maria Cecilia ScimiaWalter J Koch
Feb 4, 2019·Hormone Molecular Biology and Clinical Investigation·Aykut DundarCengiz Arslan
Feb 9, 2017·Frontiers in Molecular Neuroscience·Yili WuBo Bai
Jun 8, 2018·Frontiers in Physiology·Marta B WysockaDorota Nowak
Dec 2, 2020·Toxins·Bogusz TrojanowiczMatthias Girndt
Oct 30, 1998·Biochemical and Biophysical Research Communications·K TatemotoM Fujino

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.