Low sulfide levels and a high degree of cystathionine β-synthase (CBS) activation by S-adenosylmethionine (SAM) in the long-lived naked mole-rat

Redox Biology
Maja DziegelewskaMatthias Platzer

Abstract

Hydrogen sulfide (H2S) is a gaseous signalling molecule involved in many physiological and pathological processes. There is increasing evidence that H2S is implicated in aging and lifespan control in the diet-induced longevity models. However, blood sulfide concentration of naturally long-lived species is not known. Here we measured blood sulfide in the long-lived naked mole-rat and five other mammalian species considerably differing in lifespan and found a negative correlation between blood sulfide and maximum longevity residual. In addition, we show that the naked mole-rat cystathionine β-synthase (CBS), an enzyme whose activity in the liver significantly contributes to systemic sulfide levels, has lower activity in the liver and is activated to a higher degree by S-adenosylmethionine compared to other species. These results add complexity to the understanding of the role of H2S in aging and call for detailed research on naked mole-rat transsulfuration.

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Citations

Aug 30, 2016·Ageing Research Reviews·Holly M Brown-Borg, Rochelle Buffenstein
Jan 16, 2018·Nature Reviews. Nephrology·Peter StenvinkelRichard J Johnson
Sep 25, 2020·International Journal of Molecular Sciences·Samantha D CreightonIva B Zovkic
Feb 1, 2021·Ageing Research Reviews·Alexander S SokolovAlexey A Moskalev
Mar 7, 2021·International Journal of Molecular Sciences·Yi-Zhen WangDong-Dong Wu

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Methods Mentioned

BETA
PCR
electrophoresis
transfection
Protein Assay
RNA-seq

Software Mentioned

bcl2fastq
PrimerX
tophat
count
PAML
htseq

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