Low testosterone levels are associated with endothelial dysfunction in oophorectomized early postmenopausal women

European Journal of Endocrinology
Ciciliana Maíla Zilio RechEliete Bouskela

Abstract

The actual consequences of low testosterone levels in women remain uncertain. To assess endogenous testosterone influence on body composition, vascular and metabolic function in recent postmenopausal women. We studied 81 postmenopausal women under transdermal estradiol (E2) replacement therapy, 36 with bilateral oophorectomy (group O), and 45 controls (group C) through venous occlusion plethysmography, bioimpedance, DEXA, biochemical, hormonal, and inflammatory profile. Total testosterone level (TT) in group O was 11.0 (4.0-17.75) vs 23.0 (10.0-42.5) ng/dl in group C (P=0.001). Forearm blood flow, in ml/min/100  ml tissue, was lower in group O compared to group C at baseline (1.57 (1.05-2.47) vs 2.19 (1.59-2.66) P=0.036), following reactive hyperemia response (endothelium-dependent flow mediated dilatation, 3.44 (2.38-4.35) vs 4.3 (3.09-5.52), P=0.031) and following nitroglycerin (endothelium-independent dilation, 1.39 (0.99-1.7) vs 1.76 (1.15-2.0), P=0.025), with a positive correlation between TT and all parameters except for the reactive hyperemia response (r=0.233-0.312, P=0.036-0.004). The sVCAM1 levels were negatively correlated with TT (r=-0.320, P=0.005). E2 and other hormone levels, biochemical parameters and body compo...Continue Reading

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Citations

Jan 22, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Neja MudrovcicKarolina Kublickiene
Jun 25, 2017·Clinical Science·Angela K Lucas-HeraldRhian M Touyz
Sep 5, 2019·Medicina·Irene ScavelloLinda Vignozzi
Apr 17, 2020·Biology of Sex Differences·Kerrie L MoreauKerry L Hildreth

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