Low-threshold Ca2+-associated bursts are rare events in the LGN of the awake behaving monkey

Journal of Neurophysiology
Octavio RuizVivien A Casagrande

Abstract

It has been proposed that low-threshold Ca2+ (LT)-associated bursts in the lateral geniculate nucleus (LGN) of awake animals communicate significant or unexpected visual events to cortex. The present study investigated this hypothesis by examining the incidence of LT bursts in 146 cells recorded from the LGN of three macaque monkeys. Bursts were defined as clusters of two or more action potentials separated by not more than 4 ms and preceded by a > or = 100-ms quiescent interval. The incidence of bursts was examined in several intensive-training Go-NoGo and target selection tasks as well as in training-free tasks where natural scenes with both familiar and novel contents were shown. Our chief findings were as follows. 1) Bursts occur in the majority of cells under every condition tested, 2) burst incidence is very low (<1 burst every 10 s), 3) bursts occur in association with a receptive field stimulus on average only once every 23 times in 65% of cells tested, 4) cells responding with bursts to the stimulus also tended to exhibit higher levels of spontaneous bursting, 5) the presence of bursts did not depend on the novelty of the stimulus or its behavioral relevance. When the monkeys explored static natural scenes, 6) bursts w...Continue Reading

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Citations

Sep 23, 2008·Current Opinion in Neurobiology·Farran Briggs, W Martin Usrey
Dec 7, 2007·NeuroImage·Johannes Sarnthein, Daniel Jeanmonod
May 13, 2006·Neuroscience·G M AlexanderD W Godwin
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May 29, 2015·Journal of Neurophysiology·Yaoguang JiangVivien A Casagrande
Oct 20, 2015·Reviews in the Neurosciences·Theodore G Weyand
Nov 1, 2015·Annual Review of Vision Science·W Martin Usrey, Henry J Alitto

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