Low-threshold spiking interneurons perform feedback inhibition in the lateral amygdala

Brain Structure & Function
Çağrı Temuçin ÜnalM McLean Bolton

Abstract

Amygdala plays crucial roles in emotional learning. The lateral amygdala (LA) is the input station of the amygdala, where learning related plasticity occurs. The LA is cortical like in nature in terms of its cellular make up, composed of a majority of principal cells and a minority of interneurons with distinct subtypes defined by morphology, intrinsic electrophysiological properties and neurochemical expression profile. The specific functions served by LA interneuron subtypes remain elusive. This study aimed to elucidate the interneuron subtype mediating feedback inhibition. Electrophysiological evidence involving antidromic activation of recurrent LA circuitry via basolateral amygdala stimulation and paired recordings implicate low-threshold spiking interneurons in feedback inhibition. Recordings in somatostatin-cre animals crossed with tdtomato mice have revealed remarkable similarities between a subset of SOM+ interneurons and LTS interneurons. This study concludes that LTS interneurons, most of which are putatively SOM+, mediate feedback inhibition in the LA. Parallels with cortical areas and potential implications for information processing and plasticity are discussed.

References

Apr 1, 1990·Brain Research. Developmental Brain Research·G ForloniJ T Coyle
Jan 1, 1993·Experimental Brain Research·G C PapadopoulosJ G Parnavelas
Jan 1, 1993·Neuroscience·A J McDonald, J R Augustine
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·H MarkramM Tsodyks
Jun 27, 1998·Progress in Neurobiology·A J McDonald
Aug 28, 1998·Trends in Neurosciences·L W Swanson, G D Petrovich
May 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·B CauliE Audinat
Jun 9, 2000·Annual Review of Neuroscience·J E LeDoux
Jul 19, 2002·Nature·Nace L GoldingNelson Spruston
Jun 20, 2003·Journal of Neurophysiology·Michael BeierleinBarry W Connors
May 6, 2006·The Journal of Physiology·Björn M KampaGreg J Stuart
May 12, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yunyong MaAriel Agmon
Jul 21, 2006·The Journal of Comparative Neurology·Donald Gordon RainnieAlexander Joseph McDonald
Nov 23, 2006·The Journal of Comparative Neurology·Jay F MullerAlexander J McDonald
Jan 20, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alan R Woodruff, Pankaj Sah
May 21, 2010·Journal of Neurophysiology·Ludmila SosulinaHans-Christian Pape
Nov 26, 2010·Neuropharmacology·Jay SpampanatoPankaj Sah
Mar 26, 2011·Neuron·Elodie Fino, Rafael Yuste
Jan 17, 2012·Nature Neuroscience·Matthew Lovett-BarronAttila Losonczy
Jun 23, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anne MarowskyMichael Arand
Oct 13, 2012·Nature·Hillel AdesnikMassimo Scanziani
Sep 6, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dongbeom KimSatish S Nair
Nov 29, 2013·The Journal of Comparative Neurology·Gunes UnalDenis Paré
Feb 4, 2014·Current Opinion in Neurobiology·Marco Capogna
May 13, 2014·Nature·Steffen B E WolffAndreas Lüthi
Oct 24, 2015·Neuron·Johannes J LetzkusAndreas Lüthi
Mar 26, 2016·Frontiers in Neuroanatomy·Viktória K VereczkiNorbert Hájos
May 27, 2016·Nature Reviews. Neuroscience·Joanna Urban-Ciecko, Alison L Barth

❮ Previous
Next ❯

Citations

Jun 29, 2021·Frontiers in Neural Circuits·Norbert Hájos
Aug 24, 2021·Neurobiology of Learning and Memory·Kirstie A CummingsRoger L Clem

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic

Software Mentioned

clampfit
SPSS
NeurolucidaTM
Origin

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Brain Circuits in Emotional Learning

The neuronal circuits within the cortico-limbic brain regions form networks that mediate emotional behavior. Areas specific to emotional learning include the basal amygdala and sublenticular extended amygdala region along with a supplemental motor area. Discover the latest research on brain circuits in emotional learning here.