Low thymidylate synthase expression in the primary tumor predicts favorable clinical outcome in resected gastric cancer patients treated with adjuvant tegafur

Oncology
Juan J GrauPere Gascón

Abstract

To assess the thymidylate synthase protein (TS) in tumor cells of resected gastric cancer patients treated with adjuvant tegafur (TG), we reviewed the outcome of 94 randomized patients treated either with adjuvant TG plus mitomycin C (MMC) or MMC alone. TS was determined in 76 out of 94 patients, previously randomized to receive adjuvant TG, 500 mg/m(2)/day p.o. for 6 months plus four courses of MMC, 10- 20 mg/m(2) i.v. every 6 weeks or MMC alone. An immunohistochemical assessment with the monoclonal antibody TS-106 was performed. Low TS was observed in 38 patients (20 treated with TG-MMC and 18 with MMC) and high TS in the other 38 patients (21 treated with TG-MMC and 17 with MMC). After 10 years' median follow-up time, 61% of adjuvant TG-MMC patients and 43% of MMC patients were alive and disease-free. Disease-free survival and overall survival were significantly better for patients treated with TG-MMC compared to MMC adjuvant (p = 0.0277 and p = 0.05), and low-TS compared to high-TS patients (p = 0.0184 and p = 0.0198). In 38 low-TS patients we observed an 83% chance to be disease-free in TG-MMC-treated patients and 55% in MMC-treated patients (p = 0.04). A low TS level determines a subset of patients that may benefit from a...Continue Reading

Citations

Jun 13, 2006·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Tetsuro Kubota, Larry Weisenthal
Sep 5, 2006·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Wataru Ichikawa
Aug 23, 2005·Expert Review of Anticancer Therapy·Gauri Varadhachary, Jaffer A Ajani
Oct 5, 2018·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Min Hwan KimHyun Cheol Chung
Mar 27, 2015·Technology in Cancer Research & Treatment·Jingyue SunJingdong He
May 18, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kazuyuki KawakamiMauro Magnani

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