Low total and free triiodothyronine levels are associated with insulin resistance in non-diabetic individuals

Scientific Reports
Chih-Yuan WangTien-Chun Chang

Abstract

This study examined associations of thyroid hormone levels and insulin resistance (IR) in non-diabetic individuals. Using a cross-sectional design, 2007-2008 data from the National Health and Nutrition Examination Survey (NHANES) were analyzed. NHANES participants ≥20 years of age with complete data of interest were included. The homeostatic model assessment (HOMA) was used to quantify IR, and treated as a continuous variable. Self-reported diabetes or a fasting glucose ≥7 mmol/L were used as criteria to exclude diabetic subjects. Race, liver function, obesity, hypertension, dyslipidemia, smoking, physical activity, vigorous recreational activity, 2-hour glucose, hemoglobin A1C (HbA1C), high-density lipoprotein, triglyceride, vitamin D and C-reactive protein were covariates significantly associated with HOMA-IR. A total of 1,560 non-diabetic subjects were included in the analysis. When adjusted for all factors significant in the univariate analysis (race, liver function, obesity, hypertension, dyslipidemia, smoking, physical activity, vigorous recreational activity, 2-hour glucose, HbA1C, high-density lipoprotein, triglyceride, vitamin D, and CRP) low total triiodothyronine (TT3) and low free T3 (FT3) were significantly associa...Continue Reading

References

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Citations

Jun 4, 2020·Therapeutic Advances in Endocrinology and Metabolism·Patrícia de Fátima Dos Santos TeixeiraCarmen Cabanelas Pazos-Moura
Oct 24, 2019·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Neil E CaporasoBarry I Graubard
Apr 4, 2021·International Journal of Environmental Research and Public Health·Nijole KazukauskieneNarseta Mickuviene

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Methods Mentioned

BETA
glycation

Software Mentioned

SPSS

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