Low transplant-related mortality with allogeneic stem cell transplantation in elderly patients

Bone Marrow Transplantation
M Y ShapiraR Or

Abstract

Historically, age >60 years was considered a contraindication for allogeneic stem cell transplantation (allo-SCT). In recent years, elderly (>60 years) patients have become eligible for allo-SCT due to the application of reduced intensity conditioning (RIC). The present report summarizes our cumulative experience in a cohort of 17 elderly patients (age 60-67, median 62.5 years) with hematological malignancies treated with 18 allo-SCT procedures, mostly nonmyeloablative. In all, 14 patients received fludarabine and busulfan/busulfex regimen, three patients were conditioned with the fludarabine and low-dose TBI and one patient received busulfan alone. All patients displayed tri-lineage engraftment. The time to recovery of absolute neutrophil count >/=0.5 x 10(9)/l was 9-27 days (median 14 days). The time interval to platelet recovery >/=20 x 10(9)/l was 3-96 days (median 11 days). Veno-occlusive disease occurred only in 3/18 procedures and subsided with conventional treatment. Nonfatal transplant-related complications occurred in 6/18 (33.3%) procedures including: renal failure, arrhythmia, CNS bleeding, cystitis, typhlitis and gastrointestinal bleeding. Transplant-related mortality occurred in 6/18 (33.3%) episodes. Of the 17 pa...Continue Reading

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Citations

May 23, 2013·Transplantation·Karin HockStefan G Tullius
Oct 12, 2011·Onkologie·Christoph BusemannWilliam H Krüger
Jun 27, 2014·Journal of Cancer Research and Clinical Oncology·Christian SpäthWilliam H Krüger
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Oct 6, 2015·Bone Marrow Transplantation·K MiyaoUNKNOWN Nagoya Blood and Marrow Transplantation Group
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Jan 16, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·John KorethVincent T Ho
Jul 26, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Patrice ChevallierMohamad Mohty
Dec 13, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Eiji KusumiShuichi Taniguchi
Sep 27, 2005·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Vikas GuptaThomas Kiss
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Aug 13, 2011·Bulletin du cancer·Luca CastagnaSabine Furst

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