PMID: 9658014Jul 11, 1998Paper

Low ubiquinone content in Escherichia coli causes thiol hypersensitivity

Journal of Bacteriology
H ZengG T Javor

Abstract

Thiol hypersensitivity in a mutant of Escherichia coli (IS16) was reversed by complementation with a plasmid that carried the ubiX gene. The mutant had low ubiquinone content. Complementation elevated the ubiquinone level and eliminated thiol hypersensitivity. Analysis of chromosomal ubiX genes indicated that both parent and mutant strains were ubiX mutants. The low ubiquinone content of IS16 was possibly caused by a ubiD ubiX genotype. A ubiA mutant also exhibited thiol hypersensitivity. Neither IS16 nor the ubiA mutant strain could produce alkaline phosphatase (in contrast to their parent strains) after 2 h of induction, thus showing Dsb- phenotypes. The phenomena of thiol hypersensitivity and low ubiquinone content may be linked by their connections to the periplasmic disulfide bond redox machinery.

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Citations

Jun 8, 2000·FEMS Microbiology Reviews·R A FabianekL Thöny-Meyer
Oct 13, 2000·Journal of Bacteriology·H Zhang, G T Javor
Aug 9, 2001·Proceedings of the National Academy of Sciences of the United States of America·D GoldstoneP Metcalf
Jan 15, 2014·Journal of Bacteriology·Ryota HideseNobuyoshi Esaki
Apr 28, 2000·Microbiology·B Søballe, R K Poole
Nov 14, 2001·The Journal of Biological Chemistry·Abdelmadjid K HihiSiegfried Hekimi
Nov 2, 2016·Journal of Industrial Microbiology & Biotechnology·George N Bennett, Ka-Yiu San
Aug 1, 2009·EcoSal Plus·R Meganathan, Ohsuk Kwon
Feb 6, 2004·Biochimica Et Biophysica Acta·Mikael TurunenGustav Dallner
Sep 25, 2007·Archives of Biochemistry and Biophysics·Melissa GulmezianGeorge T Javor

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