Low-voltage electrically-enhanced microextraction as a novel technique for simultaneous extraction of acidic and basic drugs from biological fluids

Journal of Chromatography. a
Shahram SeidiAli Esrafili

Abstract

In the present work, for the first time a new set-up was presented for simultaneous extraction of acidic and basic drugs using a recent novel electrically-enhanced microextraction technique, termed electromembrane extraction at low voltages followed by high performance liquid chromatography with ultraviolet detection. Nalmefene (NAL) as a basic drug and diclofenac (DIC) as an acidic drug were extracted from 24 mL aqueous sample solutions at neutral pH into 10 μL of each acidified (HCl 50 mM) and basic (NaOH 50 mM) acceptor solution, respectively. Supported liquid membranes including 2-nitrophenyl octyl ether containing 5% di-(2-ethylhexyl) phosphate and 1-octanol were used to ensure efficient extraction of NAL and DIC, respectively. Low voltage of 40 V was applied over the SLMs during 14 min extraction time. The influences of fundamental parameters affecting the transport of target drugs were optimized using experimental design. Under optimal conditions, NAL and DIC were extracted with extraction recoveries of 12.5 and 14.6, respectively, which corresponded to preconcentration factors of 300 and 350, respectively. The proposed technique provided good linearity with correlation coefficient values higher than 0.9956 over a concen...Continue Reading

References

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Citations

Apr 19, 2013·Journal of Chromatographic Science·Vamsi Krishna MarothuRamanasri Vusa
Sep 18, 2014·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Mostafa KhajehMousa Bohlooli
Oct 1, 2015·Journal of Separation Science·Chuixiu HuangStig Pedersen-Bjergaard
May 9, 2014·Electrophoresis·Astrid Gjelstad, Stig Pedersen-Bjergaard
Oct 13, 2015·Journal of Chromatography. a·Yousef Abdossalami AslHatam Amanzadeh
Mar 24, 2016·Bioanalysis·Maryam RezazadehShahram Seidi
Feb 12, 2015·Journal of Pharmaceutical and Biomedical Analysis·Chuixiu HuangStig Pedersen-Bjergaard
Feb 26, 2015·Journal of Chromatographic Science·Mostafa KhajehA A Moosavi-Movahedi
Jan 13, 2015·Journal of Pharmaceutical and Biomedical Analysis·Mohammad TajikBehnam Ebrahimpour
Dec 12, 2013·Journal of Chromatography. a·Maryam RezazadehLeila Arjomandi-Behzad
Mar 10, 2015·Bioanalysis·Knut Fredrik SeipStig Pedersen-Bjergaard
Sep 4, 2016·Analytica Chimica Acta·Yousef Abdossalami AslMaryam Rezazadeh
Dec 13, 2018·Bioanalysis·Shahram SeidiReza Alizadeh
Dec 11, 2020·Talanta·Hana Bavlovič PiskáčkováStig Pedersen-Bjergaard
Apr 23, 2021·Analytical and Bioanalytical Chemistry·Elia SantigosaMaría Ramos-Payán

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