Low-volume goat milk transmission of classical scrapie to lambs and goat kids

PloS One
Sally A Madsen-BouterseDavid A Schneider

Abstract

The risk of classical scrapie transmission in small ruminants is highest during the neonatal period with the placenta recognized as a significant source of infection. Milk has also been identified as a source of scrapie with sheep-to-sheep transmission occurring after neonatal consumption of as little as 1-2 liters of milk; concurrent mastitis due to small ruminant lentivirus (SRLV) infection may be associated with increased scrapie transmission via milk in sheep. In contrast, goat-to-sheep transmission has been documented only after prolonged consumption of >30 liters of milk. The goal of the current study was to assess transmission of scrapie to goat kids and lambs following low volume, short duration consumption of milk from infected goats. Milk from two does (female goats) with pre-clinical scrapie was fed to four goat kids (≤4.5 L each) and four lambs (~3.7 L each) beginning ~24 hours after birth. Scrapie transmission was detected in three sheep as early as 18 months post inoculation; transmission was also detected in two goats but not until postmortem analyses at 33 months post inoculation. Each milk donor goat also had naturally-acquired infection with SRLV. Different degrees of lymphohistiocytic inflammation and PrPSc a...Continue Reading

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Citations

Nov 27, 2020·Frontiers in Veterinary Science·Najiba MammadovaJustin J Greenlee
Jul 16, 2021·EFSA Journal·UNKNOWN European Food Safety Authority (EFSA)Pietro Stella

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Datasets Mentioned

BETA
M60855

Methods Mentioned

BETA
PCR
biopsy
biopsies
ELISA

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