Low-volume PEG plus ascorbic acid versus high-volume PEG as bowel preparation for colonoscopy

doi:10.3109/00365521003734158

PMID: 20602568DOI: 10.3109/00365521003734158Jul 7, 2010Paper

Low-volume PEG plus ascorbic acid versus high-volume PEG as bowel preparation for colonoscopy

Scandinavian Journal of Gastroenterology

Sietske CorporaalJan J Koornstra

Abstract

High volumes of polyethylene glycol (PEG)-based solutions as bowel preparation for colonoscopy are effective, but often poorly tolerated. To compare a 2 l PEG-based solution combined with ascorbic acid (PEG + Asc) with 4 l PEG-based solution (PEG). In a single blind, quasi-randomized, prospective study, 350 patients undergoing colonoscopy received 2 l of PEG + Asc or 4 l of PEG. For morning procedures, the total dose of PEG + Asc was taken the evening before, for afternoon colonoscopies, PEG + Asc was given as a split dose. The 4 l PEG preparation was given as a split dose. Efficacy of preparation was scored on a five-point scale in three different colon segments. Patients' experiences were evaluated using a questionnaire. From 307 patients (149 PEG + Asc, 158 PEG), results were available. Successful colon cleansing was achieved in 90.6% in the PEG + Asc group compared to 96% in the PEG group (not significant). In patients prepared with PEG + Asc, bowel cleansing was worse when patients underwent colonoscopy in the morning, compared to afternoon procedures. Side-effects and patients' experiences were similar in the PEG + Asc and PEG group. Low-volume PEG + ascorbic acid has comparable efficacy and tolerability as high-volume PE...Continue Reading

Associated Clinical Trials

Low-volume Polyethylene Glycol Bowel Preparation for Colonoscopy

Aug 28, 2013·Felix Tellez

Colon Cleansing Quality of Polyethylene Glycol Compared With Polyethylene Glycol Plus Ascorbic Acid.

Feb 27, 2014·Alberto Domínguez Rodríguez

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