Low vs. high concentration of levobupivacaine for post-operative epidural analgesia: influence of mode of delivery

Acta Anaesthesiologica Scandinavica
M DerneddeJ G Boogaerts

Abstract

Although the use of continuous epidural infusion (CEI) and patient-controlled epidural analgesia (PCEA) has become commonplace in pain management, there is still controversy regarding the relative effects of mass, volume and concentration of the local anaesthetic. This prospective study evaluated the influence of two concentrations of levobupivacaine on the quality of analgesia in two modes of delivery after lower abdominal surgery. Eighty-two patients were randomly assigned to four groups to receive combined low thoracic epidural analgesia and general anaesthesia followed by post-operative CEI or PCEA using 1.5 or 5 mg/ml levobupivacaine (15 mg/h in CEI and bolus 5 mg, lockout 20 min in PCEA). Sensory block, pain scores, levobupivacaine and rescue morphine consumption, motor blockade, haemodynamics, side-effects and patient satisfaction were registered within 48 h. The four groups were similar with regard to demographics, quality of analgesia, morphine consumption and satisfaction rate. No difference in the quality of analgesia was observed for the two modes of delivery with regard to the concentration of levobupivacaine, but the consumption of the local anaesthetic was higher in the CEI groups. The Bromage scores in the PCEA ...Continue Reading

References

Mar 1, 1978·Anesthesia and Analgesia·A GalindoR Pena
Aug 1, 1978·British Journal of Anaesthesia·E M GrundyA P Winnie
Jan 1, 1965·Acta Anaesthesiologica Scandinavica. Supplementum·P R Bromage
Oct 1, 1980·British Journal of Anaesthesia·D B ScottB G Covino
Jan 7, 2000·Journal of Clinical Anesthesia·F M BardiauJ G Boogaerts
Apr 11, 2000·Acta Anaesthesiologica Scandinavica·J G BoogaertsF M Bardiau
Dec 31, 2002·Anesthesia and Analgesia·Françoise M BardiauMichaela Stadler
Mar 7, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Thomas StandlJochen Schulte Am Esch
Jul 16, 2003·Acta Anaesthesiologica Scandinavica·M DerneddeJ Boogaerts

❮ Previous
Next ❯

Citations

Sep 28, 2010·Journal of Cardiothoracic and Vascular Anesthesia·Oya Yalcin CokGulnaz Arslan
Oct 24, 2007·Peptides·Richard J Bodnar
Nov 8, 2007·Paediatric Anaesthesia·Pablo IngelmoRoberto Fumagalli
Apr 27, 2010·Acta Anaesthesiologica Scandinavica·M AllegriM Regazzi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.