PMID: 6977607Mar 1, 1982Paper

Low zone desensitization: a stimulus-specific control mechanism of cell response. Investigations on anaphylatoxin-induced platelet secretion

The Journal of Experimental Medicine
S MeuerD Bitter-Suermann

Abstract

The biologic activity of the anaphylatoxic peptides C5a and C3a is regulated efficiently at the target-cell level by the phenomenon of desensitization. Desensitization of platelets is stimulus specific and can be induced by low concentrations of anaphylatoxins without any preceding secretory event. In contrast to activation to secretion, desensitization is Ca++ independent but much more time consuming, especially at lower temperatures where both processes differ markedly in reaction velocity. This low zone desensitization insures that secretion from platelets only occurs when high amounts of anaphylatoxins are rapidly generated in the vicinity of the target-cell. Consequently, stimulus-specific unresponsiveness of the target cells can be induced by slowly increasing the concentration of the respective stimuli in their vicinity. Cellular control seems to act as a first-line mechanism of regulation, whereas the role of fluid-phase control is considered as preventing longer persistence and systemic accumulation of active anaphylatoxins.

References

Jun 1, 1979·The Journal of Clinical Investigation·J J HermanH R Colten
Jun 1, 1978·Inflammation·R O Webster, P M Henson
May 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·T E Hugli, B W Erickson
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J P GorskiH J Müller-Eberhard
Mar 1, 1979·The Journal of Cell Biology·J T O'FlahertyP A Ward
Jan 1, 1978·Scandinavian Journal of Immunology·S BeckerD Bitter-Suermann
Dec 1, 1970·The Journal of Clinical Investigation·V A Bokisch, H J Müller-Eberhard
May 1, 1973·The Journal of Experimental Medicine·E H Vallota, H J Müller-Eberhard
Sep 1, 1981·Immunopharmacology·S MeuerD Bitter-Suermann
Apr 3, 1980·The New England Journal of Medicine·H S JacobC F Moldow

❮ Previous
Next ❯

Citations

Jan 1, 1983·Springer Seminars in Immunopathology·H P Hartung, U Hadding
Jun 1, 1996·Immunotechnology : an International Journal of Immunological Engineering·A KolaJ Köhl
Nov 15, 1992·European Journal of Biochemistry·T KretzschmarJ Köhl
Jun 1, 1989·European Journal of Immunology·R Gerardy-SchahnD Bitter-Suermann
Jul 1, 1990·European Journal of Immunology·J KöhlD Bitter-Suermann
Jan 1, 1986·European Journal of Immunology·R BurgerD Bitter-Suermann
Mar 1, 1993·European Journal of Immunology·J KöhlM Casaretto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alternative Complement Pathway

The Alternative Complement Pathway is part of the innate immune system, and activation generates membrane attack complexes that kill pathogenic cells. Discover the latest research on the Alternative Complement Pathway.

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.