Lower antibody response to Porphyromonas gingivalis associated with immunoglobulin G Fcgamma receptor IIB polymorphism

Journal of Periodontal Research
Y HonmaH Yoshie

Abstract

Human FcgammaRIIB is one of the receptors for immunoglobulin G (IgG) and suppresses the activation of B lymphocytes through cross-linking with the B cell receptor via immune complexes. This function of FcgammaRIIB is essential for the negative regulation of antibody production. Our previous study has demonstrated the gene polymorphism FcgammaRIIB-I232T to be associated with periodontitis. The polymorphism FcgammaRIIB-232T has been reported to inhibit B-cell antigen receptor signaling more effectively compared to FcgammaRIIB-232I, while other groups concluded that FcgammaRIIB-232T had no ability to inhibit activatory receptors. In this study, we examined whether FcgammaRIIB-I232T polymorphism would change the IgG antibody response to the periodontopathic bacteria Porphyromonas gingivalis. Forty-seven patients with periodontitis were genotyped with the direct sequencing of genome DNA. Serum IgG and specific IgG subclass levels for the sonicate of P. gingivalis and the recombinant 40 kDa outer membrane protein (OMP) were determined. No significant difference in the total IgG level and IgG response to P. gingivalis sonicate were observed between sera from FcgammaRIIB-232T carriers and non-carriers. The FcgammaRIIB-232T carriers rev...Continue Reading

References

Jan 1, 1990·Archives of Oral Biology·Y AbikoH Takiguchi
Mar 1, 1993·International Immunology·P A WarmerdamP J Capel
Dec 31, 2002·Biochemical and Biophysical Research Communications·Yasuko ShibataYoshimitsu Abiko
Dec 4, 2003·Genes and Immunity·K YasudaH Yoshie
May 10, 2007·Oral Microbiology and Immunology·K ThihaI Ishikawa

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