Lower arterial stiffness and Framingham score after switching abacavir to tenofovir in men at high cardiovascular risk

AIDS
Kate SinnAndrew Carr

Abstract

Abacavir's effect on cardiovascular function has not been studied prospectively. We measured augmentation index (a measure of arterial stiffness) in 20 men who switched from abacavir to tenofovir. After 4 weeks, mean augmentation index reduced from 22% by 4% (P = 0.03) and Framingham risk score by 2% (P = 0.01), which was driven by lower total cholesterol (0.8 mmol/l; P = 0.002). Consistent trends were observed through week 24. Changes in C-reactive protein, interleukin-6 and D-dimer were inconsistent and only occurred from week 12. Abacavir may impair cardiovascular function by increasing total cholesterol levels.

References

Apr 9, 2004·The New England Journal of Medicine·John DaneshVilmundur Gudnason
Oct 19, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Wiktoria WojciechowskaUNKNOWN European Project on Genes in Hypertension (EPOGH)Investigators
Dec 22, 2006·The New England Journal of Medicine·Thomas J WangRamachandran S Vasan
Jun 29, 2007·Journal of Human Hypertension·H R Nakhai-PourY T van der Schouw
Jan 12, 2008·The American Journal of Medicine·Michael G ShlipakMary A Whooley
May 16, 2008·The New England Journal of Medicine·Björn ZetheliusJohan Arnlöv
Jun 19, 2008·Hypertension·Giuseppe SchillaciElmo Mannarino
Mar 14, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Cindy H BrothersDidier H Lapierre
Jul 2, 2009·JAMA : the Journal of the American Medical Association·Olle MelanderThomas J Wang
Sep 5, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jason V BakerKeith Henry
Oct 22, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Allison MartinAndrew Carr

❮ Previous
Next ❯

Citations

Dec 25, 2013·Circulation·Kunjal PatelUNKNOWN Pediatric HIV/AIDS Cohort Study (PHACS)
Jul 27, 2011·Expert Opinion on Pharmacotherapy·Giuliano Rizzardini, Patrizia Zucchi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.