Lower-body negative pressure decreases noninvasively measured intracranial pressure and internal jugular vein cross-sectional area during head-down tilt

Journal of Applied Physiology
William WatkinsBrandon R Macias

Abstract

Long-term spaceflight induces a near visual acuity change in ~50% of astronauts. In some crew members, postflight cerebrospinal fluid (CSF) opening pressures by lumbar puncture are as high as 20.9 mmHg; these members demonstrated optic disc edema. CSF communicates through the cochlear aqueduct to affect perilymphatic pressure and tympanic membrane motion. We hypothesized that 50 mmHg of lower-body negative pressure (LBNP) during 15° head-down tilt (HDT) would mitigate elevations in internal jugular vein cross-sectional area (IJV CSA) and intracranial pressure (ICP). Fifteen healthy adult volunteers were positioned in sitting (5 min), supine (5 min), 15° HDT (5 min), and 15° HDT with LBNP (10 min) postures for data collection. Evoked tympanic membrane displacements (TMD) quantified ICP noninvasively. IJV CSA was measured using standard ultrasound techniques. ICP and IJV CSA increased significantly from the seated upright to the 15° HDT posture (P < 0.05), and LBNP mitigated these increases. LBNP at 25 mmHg reduced ICP during HDT (TMD of 322.13 ± 419.17 nl) to 232.38 ± 445.85 nl, and at 50 mmHg ICP was reduced further to TMD of 199.76 ± 429.69 nl. In addition, 50 mmHg LBNP significantly reduced IJV CSA (1.50 ± 0.33 cm2) during 15...Continue Reading

References

Nov 1, 1976·Journal of Applied Physiology·A FouxA Valero
Dec 1, 1991·Journal of Applied Physiology·S E ParazynskiA Crenshaw
Apr 1, 1990·British Journal of Audiology·A ReidA P Brightwell
May 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·A ReidJ D Pickard
May 1, 1987·British Journal of Audiology·R J MarchbanksD Bateman
Jun 1, 1973·Brain : a Journal of Neurology·H DavsonJ R Hollingsworth
Dec 15, 1984·American Journal of Ophthalmology·R N WeinrebT R Friberg
Jun 1, 1994·Journal of Clinical Pharmacology·J B Charles, C M Lathers
Sep 1, 1993·The Clinical Investigator·J DraegerC Stern
Jul 1, 1996·Journal of Applied Physiology·J C BuckeyC G Blomqvist
Jul 1, 1996·Journal of Applied Physiology·N FoldagerP Norsk
Oct 23, 1998·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·M SamuelR J Marchbanks
Jul 31, 2004·The Journal of Physiology·J GisolfJ M Karemaker
May 3, 2008·Ophthalmology·John P BerdahlDouglas H Johnson
Aug 23, 2008·Investigative Ophthalmology & Visual Science·John P BerdahlR Rand Allingham
Jul 16, 2013·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Thomas H MaderDonald R Pettit
Sep 21, 2013·Journal of Applied Physiology·Sara QvarlanderAnders Eklund
Feb 1, 2014·Aviation, Space, and Environmental Medicine·Li-Fan Zhang, Alan R Hargens
Jan 8, 2015·Aviation, Space, and Environmental Medicine·Brandon R MaciasAlan R Hargens
Oct 16, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lonnie Grove PetersenMarianne Juhler
Jun 29, 2016·Annals of Neurology·Anders EklundJan Malm
Jan 17, 2017·The Journal of Physiology·Justin S LawleyBenjamin D Levine

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Citations

Aug 28, 2020·Frontiers in Physiology·Stuart M C LeeMichael B Stenger
Dec 6, 2017·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Laura PelizzariRobert Zivadinov
Sep 18, 2020·Journal of Applied Physiology·Justin S LawleyBenjamin D Levine
Nov 17, 2020·Current Opinion in Ophthalmology·Emily A Khossravi, Alan R Hargens
Mar 24, 2021·Aerospace Medicine and Human Performance·Jason DavidAlexey Grishin
Nov 14, 2020·Investigative Ophthalmology & Visual Science·Laura P PardonNimesh B Patel
Apr 16, 2021·Journal of Applied Physiology·Karina Marshall-GoebelMichael B Stenger
Jul 14, 2021·The Journal of Vascular Access·Mariana Garcia-LealRodrigo Enrique Elizondo-Omaña

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