Lower bone mass in prepubertal overweight children with prediabetes.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Norman K PollockCatherine L Davis

Abstract

Childhood studies of the fat-bone relationship are conflicting, possibly reflecting the influence of metabolic abnormalities in some but not all obese children. Bone mass was compared between prepubertal overweight children with (n = 41) and without (n = 99) prediabetes. Associations of bone mass with measures of total and central adiposity, glucose intolerance, insulin sensitivity, lipid profile, systemic inflammation, and osteocalcin also were determined. In 140 overweight children aged 7 to 11 years, an oral glucose tolerance test was used to identify those with prediabetes and for determination of glucose, 2-hour glucose, glucose area under the curve (AUC), insulin, 2-hour insulin, and insulin AUC. Blood samples also were assessed for lipids, C-reactive protein, and osteocalcin. Total-body bone mineral content (BMC), fat-free soft tissue mass (FFST), and fat mass (FM) were measured by dual-energy X-ray absorptiometry (DXA). Visceral adipose tissue (VAT) and subcutaneous abdominal adipose tissue (SAAT) were assessed using MRI. Total-body BMC was 4% lower in overweight children with prediabetes than in those without prediabetes after controlling for sex, race, height, and weight (p = .03). In the total sample, FM was positive...Continue Reading

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References

Mar 1, 1979·Acta Endocrinologica·P McNairI Transbøl
Oct 1, 1992·The Clinical Investigator·M M HirschlW Waldhäusl
Sep 1, 1991·Calcified Tissue International·R Bouillon
Jan 27, 1990·BMJ : British Medical Journal·J N MatthewsP Royston
Jul 1, 1985·The Journal of Clinical Investigation·N H BellS Shaw
Jun 1, 1988·The Journal of Clinical Investigation·S L HuiC C Johnston
Mar 15, 1995·Annals of Internal Medicine·P L van DaeleH A Pols
Mar 15, 1995·American Journal of Epidemiology·N D BrenerB I Williams
Oct 1, 1996·Medicine and Science in Sports and Exercise·C CassellB Specker
Sep 24, 1998·The Journal of Clinical Endocrinology and Metabolism·C M GundbergH Rosen
Feb 2, 1999·Medicine and Science in Sports and Exercise·S OwensW Thompson
Dec 22, 1999·The Journal of Clinical Endocrinology and Metabolism·L K BachrachR Marcus
Oct 12, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A GouldingS M Williams
Mar 7, 2001·The Journal of Clinical Endocrinology and Metabolism·A V SchwartzUNKNOWN Study of Osteoporotic Features Research Group
Jul 14, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D L SkaggsV Gilsanz
Aug 11, 2001·Free Radical Biology & Medicine·N ModyL L Demer
Oct 27, 2001·Diabetes·M I Goran, B A Gower
Mar 15, 2002·The New England Journal of Medicine·Ranjana SinhaSonia Caprio
Jul 8, 2003·The Journal of Endocrinology·T AhmadA Kreicbergs
Nov 18, 2003·Acta Diabetologica·K J EllisS A Abrams
Jun 4, 2004·The New England Journal of Medicine·Ram WeissSonia Caprio
Jul 28, 2004·The American Journal of Clinical Nutrition·Mary B LeonardBabette S Zemel
Oct 27, 2004·Journal of the American Society of Nephrology : JASN·Brent E Wisse
Apr 20, 2006·The Journal of Clinical Endocrinology and Metabolism·E M ClarkJ H Tobias
Jun 3, 2006·Pediatrics·Erica D TaylorJack A Yanovski
Jun 8, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A H HolmbergK Akesson
Oct 19, 2006·The Journal of Clinical Endocrinology and Metabolism·Agnieszka JanickaVicente Gilsanz
May 16, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lorenz C HofbauerHarald Dobnig
Aug 19, 2007·Cell·Na Kyung LeeGerard Karsenty
Nov 10, 2007·The American Journal of Clinical Nutrition·Norman K PollockRichard D Lewis
Jan 10, 2008·Diabetes Care·UNKNOWN American Diabetes Association
Mar 20, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L Joseph MeltonSundeep Khosla
Apr 30, 2008·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Catherine M GordonHeidi J Kalkwarf
Sep 10, 2008·Nature Clinical Practice. Endocrinology & Metabolism·Rhonda Bentley-LewisEllen W Seely
May 26, 2009·Journal of Bone and Mineral Metabolism·Wagner Luiz do PradoAna Raimunda Dâmaso
Jun 18, 2009·The Journal of Clinical Endocrinology and Metabolism·Vicente GilsanzSteven D Mittelman
Jul 15, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Moira A PetitUNKNOWN Osteoporotic Fractures in Men (MrOs) Study Group

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Citations

Mar 9, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Y SheuJ A Cauley
Mar 5, 2011·Current Osteoporosis Reports·Yahtyng Sheu, Jane A Cauley
Apr 22, 2011·The Journal of Clinical Endocrinology and Metabolism·Norman K PollockCatherine L Davis
Feb 6, 2014·Journal of Endocrinological Investigation·L UtsalJ Jürimäe
May 27, 2014·Journal of Endocrinological Investigation·Ernesto MaddaloniSilvia Manfrini
May 31, 2014·Bone·Valéria Nóbrega da SilvaJosé Eduardo Corrente
Nov 28, 2012·Cellular and Molecular Life Sciences : CMLS·H Sadie-Van GijsenW F Ferris
Sep 26, 2013·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Barbara A Gower, Krista Casazza
Mar 25, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sogol Mostoufi-MoabMary B Leonard
Nov 15, 2011·Journal of Clinical Nursing·Estela BlancoSheila Gahagan
May 6, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Joshua N FarrScott B Going
Nov 19, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Adrian SayersJon H Tobias
Mar 4, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Roberto J FajardoMary L Bouxsein
Mar 31, 2015·Molecular and Cellular Endocrinology·Norman K Pollock
Apr 23, 2014·Research Quarterly for Exercise and Sport·Scott GoingMegan Hetherington-Rauth
Jan 15, 2011·The Journal of Pediatrics·Norman K PollockYanbin Dong
Aug 29, 2014·Arquivos brasileiros de endocrinologia e metabologia·Leila C B ZanattaCarolina A M Kulak
Oct 21, 2014·BoneKEy Reports·Krista CasazzaDavid A Fields
Oct 31, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Natalie A GlassSteven M Levy
Oct 13, 2018·The Journal of Clinical Endocrinology and Metabolism·Joseph M KindlerConnie M Weaver
Jun 21, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Joseph M KindlerRichard D Lewis
Aug 12, 2020·Diabetes Care·Joseph M KindlerBabette S Zemel
Jun 11, 2017·Scientific Reports·Emilie NormandValérie Marcil
Jul 5, 2018·Annals of Pediatric Endocrinology & Metabolism·Paul Dimitri
May 16, 2019·Journal of Obesity & Metabolic Syndrome·Paul Dimitri
Mar 29, 2020·Critical Reviews in Clinical Laboratory Sciences·Wojciech J BilinskiGrazyna Sypniewska
Mar 31, 2012·Arquivos brasileiros de endocrinologia e metabologia·Raquel M S CamposAna R Dâmaso
Jan 6, 2017·Nutrition & Metabolism·Valéria Nóbrega da SilvaTamara Beres Lederer Goldberg
Sep 17, 2019·World Journal of Diabetes·Silvia Costantini, Caterina Conte
Oct 12, 2018·Archives of Endocrinology and Metabolism·Leila C B ZanattaCarolina A Moreira
Dec 26, 2016·Calcified Tissue International·Joshua N Farr, Paul Dimitri
Jun 13, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Megan Hetherington-RauthScott B Going
Aug 17, 2018·Diabetes Research and Clinical Practice·Namrata SanjeeviTonja R Nansel
Apr 11, 2021·Archives of Osteoporosis·Fariba KarimiMohammad Hossein Dabbaghmanesh
Aug 14, 2021·Journal of Diabetes and Its Complications·Wojciech J BilinskiGrazyna Sypniewska

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