Lower Circulating miR-122 Level in Patients with HNF1A Variant-Induced Diabetes Compared with Type 2 Diabetes

Journal of Diabetes Research
Xiuting HuangLinong Ji

Abstract

miR-122, the expression of which is regulated by several transcription factors, such as HNF1A, was recently reported to be associated with type 2 diabetes (T2DM) and hepatocellular carcinoma. HNF1A variants can cause diabetes and might be involved in the development of primary liver neoplasm. Differences in miR-122 expression among different types of diabetes have not been studied. This study aimed to investigate differences in serum miR-122 levels in Chinese patients with different forms of diabetes, including T2DM, type 1 diabetes (T1DM), HNF1A variant-induced diabetes (HNF1A-DM), glucokinase variant-induced diabetes (GCK-DM), and mitochondrial A3243G mutation-induced diabetes (MDM). In total, 12 HNF1A-DM patients, 24 gender-, age-, and body mass index-matched (1 : 2) T2DM patients and 24 healthy subjects were included in this study. In addition, 30 monogenic diabetes (11 GCK-DM and 19 MDM) and 17 T1DM patients were included. Fasted blood biochemistry and miR-122 were measured. The results showed that the HNF1A-DM patients had lower miR-122 levels [0.046 (0.023, 0.121)] than T2DM patients [0.165 (0.036, 0.939), P = 0.02] and healthy controls [0.249 (0.049, 1.234), P = 0.019]. The area under the curve of the receiver operating...Continue Reading

References

May 15, 2002·Current Biology : CB·Mariana Lagos-QuintanaThomas Tuschl
Nov 5, 2003·Gastroenterology·Yannick BacqJessica Zucman-Rossi
Dec 4, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Robert H CostaXinhe Wang
Feb 7, 2006·Cell Metabolism·Christine EsauBrett P Monia
Feb 26, 2008·Diabetologia·S EllardUNKNOWN European Molecular Genetics Quality Network (EMQN) MODY group
Aug 4, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·E SchoberUNKNOWN DPV-Wiss Initiative of the German Working Group for Paediatric Diabetology and
Feb 4, 2010·Journal of Lipid Research·Dimitrios IliopoulosVassilis I Zannis
Sep 16, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hui XuLiang-Hu Qu
Nov 3, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chunxian ZengShi-Mei Zhuang
Nov 3, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Philip J Starkey LewisB Kevin Park
Mar 1, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Tim J McDonaldIan S Young
Jul 19, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Carlos Fernández-Hernando
May 28, 2013·Journal of Hepatology·J S B WillsonJ L McCall
Jul 3, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Verena KöberleOliver Waidmann
Feb 18, 2014·Journal of Gastroenterology·Kazuhiko NakaoTatsuki Ichikawa
Feb 6, 2015·Journal of Lipid Research·Vikram Ravindra ShendeJingwen Liu
Nov 19, 2015·Acta Pharmaceutica Sinica. B·Zhihong YangLi Wang
Apr 12, 2016·Molecular and Cellular Endocrinology·Wei LiuLinong Ji
Apr 22, 2016·European Heart Journal·Peter WilleitManuel Mayr

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Citations

Apr 21, 2020·Journal of Alzheimer's Disease : JAD·Murali Vijayan, P Hemachandra Reddy
Feb 13, 2021·Journal of Diabetes·Luis Edgar González-SánchezLeticia Andrea Barajas-Nava
May 16, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Junling FuXinhua Xiao

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Methods Mentioned

BETA
electrophoresis
PCR
Assay

Software Mentioned

SPSS

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