Lower cortisol levels after oral glucose in subjects with insulin resistance and abdominal obesity

Clinical Endocrinology
J M Fernández-RealR Casamitjana

Abstract

It has been shown previously that morning cortisol levels decline after oral glucose, but no report has been published regarding the changes in serum cortisol in relation to insulin sensitivity or degree of obesity. We studied the effects of oral glucose during a standard oral glucose tolerance test on cortisol levels in 7 obese subjects (body mass index (BMI) 29.7 +/- 3.3 kg/m2) and in 8 control subjects (BMI 24.9 +/- 3.2 kg/m2). Cortisol concentrations were normalized to time 0 because of wide between subject variation. On another day, a frequently sampled intravenous glucose tolerance test with minimal model analysis was performed, obtaining the insulin sensitivity index (SI). Anthropometric measurements included different skinfolds and bioelectric impedance. The waist-to-hip ratio (WHR) was similar between the 2 groups, but abdominal skinfold was significantly higher in the obese group (OG) (158.8 +/- 42.9 vs. 113.6 +/- 27.7, P = 0.03). Fat mass, percentage of fat mass, triceps and subscapular skinfolds, systolic and diastolic blood pressure, VLDL-cholesterol, total triglycerides and VLDL-triglycerides were slightly higher in the obese group (OG). Area under the curve for glucose (AUCg) after OGTT was also significantly hig...Continue Reading

Citations

Mar 22, 2000·Metabolism: Clinical and Experimental·J M Fernández-RealW Ricart
Jan 13, 2017·European Journal of Endocrinology·María Del Mar GrasaMarià Alemany
Jun 1, 2002·Nutrition Research Reviews·E Leigh Gibson, Michael W Green
Mar 17, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Igor ElmanScott E Lukas
Jun 29, 2001·Endocrine Research·R VilàM Alemany
Jan 6, 2006·Endocrine Research·Mehtap CakirUmit Karayalcin

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