Abstract
Use of antihypertensive medication (AHM) is potentially associated with a reduced risk of dementia. Both calcium channel blockers (CCBs) and angiotensin receptor blockers (ARBs) are suggested to have a more pronounced protective effect. We aimed to study the association between different classes of AHM and dementia in older people. A subgroup of community-dwelling older people using AHM included in the 'Prevention of Dementia by Intensive Vascular Care' randomized controlled trial was studied. Incident dementia rates in participants with different AHM classes (mono and combination therapy) were compared with dementia rates in participants with any other AHM. At baseline, 1951 participants (55.3%) used AHM [mean age, 74.4 year (SD 2.5); mean SBP, 156.4 mmHg (SD 21.5)]. In total, 986 participants (50.5%) used β-blockers, 798 diuretics (40.9%), 623 angiotensin- converting enzyme inhibitors (31.9%), 522 CCBs (26.8%), and 402 ARBs (20.6%). After 6.7 years (interquartile range 6.0-7.3) of follow-up, 136 participants (7.0%) developed dementia. Both use of CCBs [hazard ratio 0.56, 95% confidence interval (95% CI) 0.36-0.87] and ARBs (hazard ratio 0.60, 95% CI 0.37-0.98) were independently associated with a decreased risk of dementia. T...Continue Reading
References
Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Oct 11, 2002·Archives of Internal Medicine·Françoise ForetteUNKNOWN Systolic Hypertension in Europe Investigators
Jul 11, 2008·Lancet Neurology·Ruth PetersUNKNOWN HYVET investigators
Jul 2, 2009·Alzheimer Disease and Associated Disorders·Andrea BradfordHardeep Singh
Oct 9, 2009·Alzheimer Disease and Associated Disorders·Edo RichardWillem A Van Gool
Dec 2, 2009·The American Journal of Geriatric Pharmacotherapy·Kairav ShahMark E Kunik
Mar 18, 2010·BMC Medical Research Methodology·Carine A BelleraSimone Mathoulin-Pélissier
Sep 21, 2011·European Journal of Preventive Cardiology·Suzanne A LigthartEric P Moll van Charante
Jan 12, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Martin PrinceCleusa P Ferri
Feb 7, 2013·BMC Medical Research Methodology·Sally R Hinchliffe, Paul C Lambert
Apr 5, 2013·Journal of Hypertension·Natacha Levi MarpillatPatrick Maison
May 4, 2013·British Journal of Pharmacology·V Nimmrich, A Eckert
Jul 3, 2013·Journal of Hypertension·Giuseppe ManciaUNKNOWN Task Force Members
Jul 18, 2014·Lancet Neurology·Sam NortonCarol Brayne
Jul 30, 2014·Journal of Hypertension·Ruth PetersJean Peters
Feb 24, 2015·CNS Drugs·Laure RouchSandrine Andrieu
Jul 31, 2016·Lancet·Eric P Moll van CharanteWillem A van Gool
Aug 6, 2016·Current Hypertension Reports·Ruth PetersSevil Yasar
Mar 8, 2017·PLoS Medicine·Emma F van BusselEric P Moll van Charante
Citations
Jun 22, 2018·Journal of Hypertension·Tessa van MiddelaarEdo Richard
Feb 5, 2019·British Journal of Pharmacology·Romain BarusRégis Bordet
May 28, 2019·The Journal of Clinical Hypertension·Yuda TuranaKazuomi Kario
Feb 27, 2018·Journal of Alzheimer's Disease : JAD·Tessa van MiddelaarEdo Richard
Dec 10, 2019·The Journal of Clinical Hypertension·Yuda TuranaKazuomi Kario
Jul 9, 2020·Journal of Psychopharmacology·Paul J HarrisonLucy Colbourne
Dec 31, 2019·Protein and Peptide Letters·Victor Teatini RibeiroAna Cristina Simões E Silva
Aug 28, 2020·Journal of Internal Medicine·I KalarS Garcia-Ptacek
Jun 20, 2019·Journal of Clinical Medicine·Esmé EgginkEdo Richard
May 24, 2019·Aging Clinical and Experimental Research·Per WändellKristina Sundquist
May 1, 2020·Cardiology Research and Practice·Ze-Min Kuang
Oct 2, 2019·Frontiers in Aging Neuroscience·Jongjoo SunJ Mikhail Kellawan
Dec 17, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jan Willem van DalenEdo Richard
Jan 19, 2021·Journal of the American Medical Directors Association·Melina G H E den BrokEdo Richard
Nov 7, 2020·Neurology·Jan Willem van DalenEdo Richard
Jan 19, 2021·Curēus·Nupur MishraStacey E Heindl
Feb 27, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Lorenza ScottiAntonella Zambon
Jan 8, 2018·Journal of the American Medical Directors Association·Edwin C K TanKristina Johnell