Lower expression of TLR2 and SOCS-3 is associated with Schistosoma haematobium infection and with lower risk for allergic reactivity in children living in a rural area in Ghana.

PLoS Neglected Tropical Diseases
Franca C HartgersMaria Yazdanbakhsh

Abstract

Helminth infections are prevalent in rural areas of developing countries and have in some studies been negatively associated with allergic disorders and atopy. In this context little is known of the molecular mechanisms of modulation involved. We have characterized the innate immune responses, at the molecular level, in children according to their helminth infection status and their atopic reactivity to allergens. The mRNA expression of several genes of the innate immune system that have been associated with microbial exposure and allergy was examined in 120 school children in a rural area in Ghana. Helminth infections were common and atopy rare in the study area. The analysis of gene expression in ex vivo whole blood samples reflected the levels of corresponding proteins. Using this approach in a population of school children in whom the presence of Schistosoma haematobium infection was associated with protection from atopic reactivity, we found that the level of TLR2 and SOCS-3, genes associated with atopy in the children, were significantly downregulated by presence of S. haematobium infection. S. haematobium infections modulate the expression of genes of the innate immune system (TLR2 and SOCS-3); these are genes that are a...Continue Reading

References

Nov 1, 1981·The Journal of Allergy and Clinical Immunology·R C AalberseJ G Clemens
Sep 1, 1993·The Journal of Allergy and Clinical Immunology·N R LynchN Alvarez
Nov 4, 2000·International Archives of Allergy and Immunology·M I AraujoE M Carvalho
Feb 22, 2001·The Journal of Experimental Medicine·A SuzukiA Yoshimura
Dec 26, 2001·International Archives of Allergy and Immunology·A H van den BiggelaarM Yazdanbakhsh
Jun 18, 2002·Infection and Immunity·Claudia BrodskynManoel Barral-Netto
Sep 20, 2002·The New England Journal of Medicine·Charlotte Braun-FahrländerUNKNOWN Allergy and Endotoxin Study Team
Sep 21, 2002·Lancet·Roger P LauenerUNKNOWN ALEX study group
Sep 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yoh-Ichi SekiMasato Kubo
Dec 18, 2002·The Journal of Experimental Medicine·Stephanie C EisenbarthKim Bottomly
Jul 9, 2003·Nature Medicine·Yoh-ichi SekiMasato Kubo
Sep 2, 2003·Nature Reviews. Immunology·Rick M Maizels, Maria Yazdanbakhsh
Jan 22, 2004·International Immunology·Minoru FujimotoTetsuji Naka
Feb 21, 2004·The Journal of Infectious Diseases·Anita H J van den BiggelaarMaria Yazdanbakhsh
Mar 5, 2004·The Journal of Infectious Diseases·Desiree van der KleijMaria Yazdanbakhsh
Mar 9, 2004·Analytical Biochemistry·Huijun Tian, Howard J Edenberg
May 4, 2004·Journal of Endotoxin Research·Hongkuan Fan, James A Cook
Sep 14, 2004·Immunological Reviews·Edward J PearceLaura Cervi
Oct 20, 2004·The Journal of Biological Chemistry·Andrea BaetzAlexander H Dalpke
Dec 4, 2004·American Journal of Respiratory Cell and Molecular Biology·German VelascoPatricia W Finn
Dec 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Colleen M KaneEdward J Pearce
Dec 14, 2004·Journal of Endotoxin Research·Catherine Ropert, Ricardo Tostes Gazzinelli
Jan 22, 2005·Current Allergy and Asthma Reports·Hermelijn H SmitsMaria Yazdanbakhsh
Feb 18, 2005·The Journal of Infectious Diseases·Subash BabuThomas B Nutman
Jun 9, 2005·The Journal of Allergy and Clinical Immunology·Petra AmoudruzEva Sverremark-Ekström
Jul 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Subash BabuThomas B Nutman
Aug 17, 2005·Advances in Immunology·Tetsuji NakaAkihiko Yoshimura
Oct 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Akemi OzakiMasato Kubo
Nov 18, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Susanne Krauss-EtschmannBerthold V Koletzko
Mar 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Subash BabuThomas B Nutman
May 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tobias MuellerDaniel K Podolsky
Dec 13, 2006·The Journal of Allergy and Clinical Immunology·Carsten FlohrJohn Britton
Jul 11, 2007·European Journal of Immunology·Brendan B L PillemerAnuradha Ray
Jul 8, 2011·The American Journal of Tropical Medicine and Hygiene·Prakash SenbagavalliSubash Babu

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Citations

Apr 20, 2014·PloS One·Lucja A LabudaAyola A Adegnika
May 23, 2014·Genes and Immunity·A S AmoahM Yazdanbakhsh
Jun 2, 2009·Immunity & Ageing : I & a·Linda MayRudi G J Westendorp
Apr 29, 2010·Current Allergy and Asthma Reports·Hermelijn H SmitsMaria Yazdanbakhsh
Mar 20, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B B ObengF C Hartgers
Jul 18, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E van Riet
Jan 25, 2011·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Harriet MpairweAlison M Elliott
Jan 30, 2014·Parasite Immunology·H MpairweA Elliott
Apr 28, 2016·International Reviews of Immunology·Amin ZakeriAlireza Haghparast
Aug 6, 2008·Pediatric Research·Carsten KöhlerMaria Yazdanbakhsh
Feb 4, 2011·Inflammatory Bowel Diseases·Guilherme Grossi Lopes CançadoRicardo Toshio Fujiwara
Sep 15, 2018·Parasite Immunology·Harriet Mpairwe, Abena S Amoah
Sep 5, 2008·Current Opinion in Allergy and Clinical Immunology·Benedicta Baffoah ObengMaria Yazdanbakhsh
Mar 31, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·David LarsonEdward Mitre
Jul 3, 2020·Immunology·Diana Cortes-Selva, Keke Fairfax

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Methods Mentioned

BETA
enzyme linked immunosorbent assay
flow cytometry
PCR
FACS
transgenic

Software Mentioned

FlowJo

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