Lower Extremity Megaprostheses in Orthopaedic Oncology

The Journal of the American Academy of Orthopaedic Surgeons
Santiago A Lozano CalderónFrancis J Hornicek

Abstract

The megaprosthesis is designed to reproduce the form and function of a removed or lost large segment of bone and accompanying soft tissues. Slow but substantial improvements in the design and surgical implementation of these devices have advanced the capacity to restore patients' functional abilities. The essential challenges include identifying the ideal materials, bonding these materials to bone and soft tissues, reproducing functional anatomy, and adapting to the growing skeleton. Failure of these devices can result from soft-tissue insufficiency, aseptic loosening, structural failures, infection, and tumor recurrence. The history of the use of megaprostheses in the pelvis, proximal femur, distal femur, total femur, and proximal tibia has shown that each anatomic area presents unique challenges. Improvements that have been made over the years will guide the development of the next generation of devices. Despite early high complication rates, these devices are a reasonable choice in the right patient.

References

Aug 1, 1979·Archives of Orthopaedic and Trauma Surgery·C BurriR M Jun
Mar 1, 1987·The Journal of Bone and Joint Surgery. British Volume·C F BradishJ N Wilson
Aug 1, 1981·The Journal of Bone and Joint Surgery. British Volume·H S DobbsR S Sneath
Jan 1, 1997·Archives of Orthopaedic and Trauma Surgery·J BrunsG Dahmen
Oct 23, 1997·The Journal of Bone and Joint Surgery. British Volume·A AbuduR S Sneath
Nov 24, 1999·Acta Orthopaedica Scandinavica·R J WirbelW E Mutschler
Mar 30, 2000·Clinical Orthopaedics and Related Research·G W BlunnJ P Cobb
Oct 19, 2001·The Journal of Arthroplasty·J BickelsM M Malawer
Jan 1, 1953·Acta Orthopaedica Scandinavica·B WALLDIUS
May 27, 1961·Lancet·J Charnley
May 13, 2006·Clinical Orthopaedics and Related Research·Georg GoshegerJendrik Hardes
Apr 18, 2007·Clinical Orthopaedics and Related Research·Alexandre ArkaderJohn H Healey
Oct 9, 2007·The Journal of Arthroplasty·Ke-Rong DaiYue-Hua Sun
Aug 1, 2009·Archives of Orthopaedic and Trauma Surgery·Adel Refaat Ahmed
Jan 27, 2011·Journal of Orthopaedic Surgery and Research·Eric R HendersonG Douglas Letson
Mar 4, 2011·The Journal of Bone and Joint Surgery. American Volume·Eric R HendersonG Douglas Letson
Jul 13, 2011·Clinical Orthopaedics and Related Research·Courtney E ShermanFranklin H Sim
Sep 14, 2011·The Knee·Pietro RuggieriMario Mercuri
Jul 19, 2012·Journal of Surgical Oncology·Andreas F MavrogenisPietro Ruggieri
Aug 27, 2013·Clinical Orthopaedics and Related Research·Andrea AngeliniPietro Ruggieri
Mar 26, 2014·Clinical Orthopaedics and Related Research·Cara A CiprianoWalter W Virkus
Apr 1, 2014·Orthopedics·Muhammad Umar Jawad, Earl W Brien

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Citations

Mar 14, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Özgür BaysalBülent Erol
Jun 8, 2021·Gait & Posture·Eileen G FowlerNicholas Bernthal

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