Lower Gene Expression of Angiotensin Converting Enzyme 2 Receptor in Lung Tissues of Smokers with COVID-19 Pneumonia.

Francesca LunardiFiorella Calabrese


Angiotensin-converting enzyme 2 (ACE-2) is the main cell entry receptor for severe acute respiratory syndrome-Coronavirus-2 (SARS-CoV-2), thus playing a critical role in causing Coronavirus disease 2019 (COVID-19). The role of smoking habit in the susceptibility to infection is still controversial. In this study we correlated lung ACE-2 gene expression with several clinical/pathological data to explore susceptibility to infection. This is a retrospective observational study on 29 consecutive COVID-19 autopsies. SARS-CoV-2 genome and ACE-2 mRNA expression were evaluated by real-time polymerase chain reaction in lung tissue samples and correlated with several data with focus on smoking habit. Smoking was less frequent in high than low ACE-2 expressors (p = 0.014). A Bayesian regression also including age, gender, hypertension, and virus quantity confirmed that smoking was the most probable risk factor associated with low ACE-2 expression in the model. A direct relation was found between viral quantity and ACE-2 expression (p = 0.028). Finally, high ACE-2 expressors more frequently showed a prevalent pattern of vascular injury than low expressors (p = 0.049). In conclusion, ACE-2 levels were decreased in the lung tissue of smokers...Continue Reading


May 21, 2009·European Journal of Clinical Investigation·G Y OuditJ Butany
Feb 26, 2020·International Journal of Oral Science·Hao XuQianming Chen
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Mar 21, 2020·European Journal of Internal Medicine·Giuseppe Lippi, Brandon Michael Henry
Apr 7, 2020·Journal of Medical Virology·Mushtaq HussainBasma Aziz
Apr 10, 2020·The European Respiratory Journal·Janice M LeungDon D Sin
Apr 10, 2020·The Lancet. Respiratory Medicine·Jason PhuaUNKNOWN Asian Critical Care Clinical Trials Group
Apr 25, 2020·Nature Medicine·Waradon SungnakUNKNOWN HCA Lung Biological Network
Apr 25, 2020·American Journal of Respiratory and Critical Care Medicine·Guoshuai CaiChristopher I Amos
Apr 27, 2020·The Journal of Infection·Zhaohai ZhengWeiliang Tang
Apr 28, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Thea MagroneEmilio Jirillo
Apr 29, 2020·The European Respiratory Journal·Patrizia RussoFabrizio Maggi
Apr 29, 2020·Respiration; International Review of Thoracic Diseases·Fengming LuoPallav L Shah
May 1, 2020·The European Respiratory Journal·Marco RossatoRoberto Vettor
May 14, 2020·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Roengrudee Patanavanich, Stanton A Glantz
May 21, 2020·The European Respiratory Journal·Janice M Leung, Don D Sin
May 21, 2020·American Journal of Respiratory and Critical Care Medicine·Haijun ZhangRonald G Crystal
May 22, 2020·The New England Journal of Medicine·Maximilian AckermannDanny Jonigk
May 24, 2020·The European Respiratory Journal·Konstantinos FarsalinosKonstantinos Poulas
Jun 11, 2020·Virchows Archiv : an International Journal of Pathology·Cristina BassoAngelo Paolo Dei Tos
Jun 13, 2020·American Journal of Respiratory and Critical Care Medicine·Francesca Polverino
Jul 10, 2020·Virchows Archiv : an International Journal of Pathology·Fiorella CalabreseFrancesca Lunardi

❮ Previous
Next ❯


Aug 25, 2021·BMC Pulmonary Medicine·M TomchaneyF Polverino

❮ Previous
Next ❯

Software Mentioned


Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Behnaz BakhshandehZohreh Jahanafrooz
Frontiers in Molecular Biosciences
Federica SaponaroRiccardo Zucchi
Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Yanwei LiRan You
© 2021 Meta ULC. All rights reserved