Lower Grade Gliomas: Relationships Between Metabolic and Structural Imaging with Grading and Molecular Factors

World Neurosurgery
Marco RivaLorenzo Bello

Abstract

Positron emission tomography (PET) is a valuable tool for the characterization of brain tumors in vivo. However, few studies have investigated the correlation between carbon-11-methionine (11C-METH) PET metrics and the clinical, radiological, histological, and molecular features of patients affected by lower grade gliomas (LGGs). The present observational study evaluated the relationships between 11C-METH PET metrics and structural magnetic resonance imaging (MRI) findings with the histomolecular biomarkers in patients with LGGs who were candidates for surgery. We enrolled 96 patients with pathologically proven LGG (51 men, 45 women; age 44.1 ± 13.7 years; 45 with grade II, 51 with grade III), who had been referred from March 2012 to January 2015 for tumor resection and had undergone preoperative 11C-METH PET. The semiquantitative metrics for 11C-METH PET included maximum standardized uptake value (SUVmax), SUV ratio to normal brain, and metabolic tumor burden (MTB). The PET semiquantitative metrics were analyzed and compared with the MRI features, histological diagnosis, isocitrate dehydrogenase-1/2 status, and 1p/19q codeletion. Histological grade was associated with SUVmax (P = 0.002), SUV ratio (P = 0.011), and MTB (P = 0.0...Continue Reading

Associated Clinical Trials

References

Aug 17, 2004·European Journal of Nuclear Medicine and Molecular Imaging·Sungeun KimMyung Chul Lee
Feb 4, 2005·Brain : a Journal of Neurology·Dirk PauleitKarl-Josef Langen
Jul 10, 2007·Acta Neuropathologica·David N LouisPaul Kleihues
Jul 20, 2007·Lancet Neurology·Karl HerholzAlan Jackson
Mar 8, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Justin S SmithMitchel S Berger
Aug 9, 2008·AJNR. American Journal of Neuroradiology·T KatoT Iwama
Oct 12, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Tarun SinghalJoseph C Mantil
Oct 26, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Norbert GalldiksKarl-Josef Langen
Aug 1, 2014·Advanced Drug Delivery Reviews·Olivier KeunenFrits Thorsen
Oct 4, 2014·Current Opinion in Oncology·Marco Riva, Lorenzo Bello
Oct 14, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Pierina NavarriaMarta Scorsetti
Jan 31, 2015·The New England Journal of Medicine·Francis S Collins, Harold Varmus
Jun 11, 2015·The New England Journal of Medicine·UNKNOWN Cancer Genome Atlas Research NetworkJianan Zhang
Jun 11, 2015·The New England Journal of Medicine·Jeanette E Eckel-PassowRobert B Jenkins
Nov 19, 2015·Radiology·Robert J GilliesHedvig Hricak
Feb 6, 2016·Journal of Neurology, Neurosurgery, and Psychiatry·Yasuo IwadateNaokatsu Saeki
Aug 19, 2016·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·D L BaileyT Beyer
Oct 18, 2016·Current Opinion in Oncology·Antonella Castellano, Andrea Falini
Jan 23, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Egesta LopciArturo Chiti
Apr 8, 2017·Nature Reviews. Neurology·Karl-Josef LangenNadim Jon Shah
Apr 10, 2017·International Journal of Computer Assisted Radiology and Surgery·Marco RivaLorenzo Bello
May 10, 2017·The Lancet Oncology·Michael WellerUNKNOWN European Association for Neuro-Oncology (EANO) Task Force on Gliomas
Oct 11, 2017·Neuro-oncology·Kosuke AokiAtsushi Natsume
Oct 19, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Antoine VergerNorbert Galldiks

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