Lower health-related quality of life predicts all-cause hospitalization among HIV-infected individuals

Health and Quality of Life Outcomes
Leonard EmurenInfectious Disease Clinical Research Program HIV Working Group

Abstract

Health-related quality of life (HRQOL) is a patient-centered outcome measure used in assessing the individual's overall functional health status but studies looking at HRQOL as a predictive tool are few. This work examines whether summary scores of HRQOL are predictive of all-cause hospitalization in the US Military HIV Natural History Study (NHS) cohort. The Short Form 36 (SF-36) was administered between 2006 and 2010 to 1711 NHS cohort members whose hospitalization records we had also obtained. Physical component summary scores (PCSS) and mental component summary scores (MCSS) were computed based on standard algorithms. Terciles of PCSS and MCSS were generated with the upper terciles (higher HRQOL) as referent groups. Proportional hazards multivariate regression models were used to estimate the hazard of hospitalization for PCSS and MCSS separately (models 1 and 2, respectively) and combined (model 3). The hazard ratios (HR) of hospitalization were respectively 2.12 times (95% CI: 1.59-2.84) and 1.59 times (95% CI: 1.19-2.14) higher for the lower and middle terciles compared to the upper PCSS tercile. The HR of hospitalization was 1.33 times (95% CI: 1.02-1.73) higher for the lower compared to the upper MCSS tercile. Other pr...Continue Reading

References

Nov 1, 1995·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·E L Idler, S V Kasl
Mar 2, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Carmina R FumazBonaventura Clotet
May 23, 2002·AIDS Research and Human Retroviruses·Simon PaulKent A Sepkowitz
May 31, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Edmund G LowrieDorian Schatell
Sep 25, 2003·Journal of Clinical Epidemiology·Denise L JacobsonUNKNOWN Outcomes Committee of the Adult AIDS Clinical Trials Group
Nov 17, 2004·HIV Medicine·A MocroftUNKNOWN EuroSIDA study group
Jan 26, 2005·Journal of the American Geriatrics Society·Jasvinder A SinghKristin L Nichol
Feb 8, 2005·Journal of General Internal Medicine·William E CunninghamRon D Hays
Dec 18, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·I Marion de Boer-van der KolkPythia T Nieuwkerk
Jan 6, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Helen M ChunUNKNOWN Infectious Disease Clinical Research Program HIV Working Group
Mar 9, 2010·The Journal of Infectious Diseases·Kimberly PelakUNKNOWN National Institute of Allergy and Infectious Diseases Center for HIV/AIDS Vaccine Immunology (CHAVI)
Jul 27, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Nancy F Crum-CianfloneUNKNOWN Infectious Disease Clinical Research Program
Dec 8, 2011·The Journal of Infectious Diseases·Helen M ChunUNKNOWN Infectious Disease Clinical Research Program HIV Working Group
Jan 10, 2012·Sexually Transmitted Infections·Alicen B SpauldingUNKNOWN Infectious Disease Clinical Research Program HIV Working Group
Oct 10, 2013·Journal of Cardiovascular Electrophysiology·Eleanor SchronSue A Thomas
Feb 12, 2015·Archives of public health = Archives belges de santé publique·Sophie DegrooteDominique M Vandijck
Aug 16, 2016·International Journal of Health Services : Planning, Administration, Evaluation·Lyndonna MarrastSteffie Woolhandler
Jun 8, 2017·PloS One·Leonard EmurenUNKNOWN Infectious Disease Clinical Research Program HIV Working Group

❮ Previous
Next ❯

Citations

Aug 21, 2019·Health and Quality of Life Outcomes·Maria Jose Fuster-RuizdeApodacaJulia Del Amo
Jan 12, 2022·HIV Medicine·Richard HardingUNKNOWN EMERGE Consortium, Horizon 2020

❮ Previous
Next ❯

Software Mentioned

SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

PloS One
Leonard EmurenInfectious Disease Clinical Research Program HIV Working Group
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Rajasekhar TanikellaMichael B Fallon
© 2022 Meta ULC. All rights reserved