Lower heart rate variability is associated with higher serum high-sensitivity C-reactive protein concentration in healthy individuals aged 46 years or more

International Journal of Cardiology
Fernando AraújoAlfredo José Mansur

Abstract

To test the hypothesis of an association between cardiac autonomic activity evaluated by heart rate variability and systemic inflammatory markers such as C-reactive protein, we studied the correlation of the indices of heart rate variability relative to serum high-sensitivity C-reactive protein (hs-CRP) in a healthy Brazilian population. Four hundred twenty-one healthy individuals aged 15-82 years (mean 40.4 years), 184 men (43.7%) and 237 women (56.3%) were enrolled between July 1998 and July 2001. The relationship between the log-transformed indices of the heart rate variability and the serum concentration of hs-CRP were analyzed stratified by age tertile using the Spearman correlation coefficient and multiple linear regression. The log standard deviation of all normal sinus RR intervals over 24 h (SDNN) (r = -0.801; p = 0.024) was independently correlated with log hs-CRP in the individuals with age in the oldest tertile (> or = 46 years). In addition, the body mass index (BMI) was independently correlated with hs-CRP in all of the age groups. In the healthy subjects aged 46 years or more the lower heart rate variability correlated with higher concentration of hs-CRP.

References

Mar 1, 1993·American Heart Journal·R E De Meersman
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·P MärzS Rose-John
Mar 21, 1998·Journal of the American College of Cardiology·K UmetaniM Atkinson
Dec 2, 1998·Basic Research in Cardiology·T FetschG Breithardt
Oct 16, 1999·Acta Physiologica Scandinavica·V E LundJ Jalonen
Nov 24, 1999·The American Journal of Cardiology·L E RohdeP M Ridker
Dec 1, 1999·Computer Methods and Programs in Biomedicine·A E AubertH Ector
Dec 11, 1999·JAMA : the Journal of the American Medical Association·M VisserT B Harris
Apr 15, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·T E Strandberg, R S Tilvis
Oct 2, 2003·Vascular Medicine·Peter Leong-Sit, Sonia S Anand
Feb 21, 2004·Journal of the American College of Cardiology·Hans K Meier-EwertJanet M Mullington
Apr 9, 2004·The New England Journal of Medicine·John DaneshVilmundur Gudnason
Nov 25, 2004·International Journal of Cardiology·Fernando AraújoAlfredo J Mansur
Jul 23, 2008·Perspectives in Vascular Surgery and Endovascular Therapy·Kimon Bekelis, Nicos Labropoulos

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Citations

Sep 22, 2010·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Roland von KänelMary A Whooley
Jun 9, 2009·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Puneet SinghChristopher M Masi
Jul 19, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Preeti ChandraRajiv Saran
Feb 2, 2013·International Archives of Occupational and Environmental Health·Annika RiegerMatthias Weippert
Jul 29, 2009·Brain, Behavior, and Immunity·Nancy Frasure-SmithBruce G Pollock
May 12, 2007·Journal of the American Geriatrics Society·Victoria J VieiraJeffrey A Woods
Jul 16, 2010·Scandinavian Journal of Medicine & Science in Sports·L Soares-MirandaJ Mota
Jan 13, 2012·Diabetes/metabolism Research and Reviews·Luisa Soares-MirandaJorge Mota
Oct 18, 2008·American Heart Journal·Rachel LampertViola Vaccarino
May 10, 2018·Psychosomatic Medicine·Mandy Xian HuBrenda W J H Penninx
Sep 29, 2017·Frontiers in Public Health·Gernot Ernst

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