Lower hemoglobin correlates with larger stroke volumes in acute ischemic stroke.

Cerebrovascular Diseases Extra
W Taylor KimberlyA Gregory Sorensen

Abstract

Hemoglobin tetramers are the major oxygen-carrying molecules within the blood. We hypothesized that a lower hemoglobin level and its reduced oxygen-carrying capacity would associate with larger infarction in acute ischemic stroke patients. We studied 135 consecutive patients with acute ischemic stroke and perfusion brain MRI. We explored the association of admission hemoglobin with initial infarct volumes on acute images and the volume of infarct expansion on follow-up images. Multivariable linear regression was performed to analyze the independent effect of hemoglobin on imaging outcomes. Bivariate analyses showed a significant inverse correlation between hemoglobin and initial volume in diffusion-weighted imaging (r = -0.20, p = 0.02) and absolute infarct growth (r = -0.20, p = 0.02). Multivariable linear regression modeling revealed that hemoglobin remained independently predictive of larger infarct volumes acutely (p < 0.005) and with greater infarct expansion (p < 0.01) after adjusting for known covariates. Hemoglobin level at the time of acute ischemic stroke associates with larger infarcts and increased infarct growth. Clarification of the mechanism of this effect may yield novel insights for therapy.

Citations

Sep 28, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Nawaf Yassi, Stephen M Davis
Feb 26, 2015·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·L KellertUNKNOWN Cervical Artery Dissection Ischaemic Stroke Patients (CADISP) study group
Apr 8, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Zhao LiYung-Ya Lin
Jun 12, 2014·Journal of Biopharmaceutical Statistics·Chia-Hao ChangMing-Hsueh Lee
Sep 12, 2014·Neurocritical Care·Andrew M NaidechUNKNOWN Participants in the International Multidisciplinary Consensus Conference on Multimodality Monitoring
Oct 23, 2014·Arquivos de neuro-psiquiatria·Gustavo José LuvizuttoRodrigo Bazan
Apr 12, 2019·Acta Neurologica Scandinavica·Halvor NaessChristopher E Kvistad
Feb 7, 2013·Current Opinion in Critical Care·Peter LeRoux
Dec 5, 2018·BMC Medical Informatics and Decision Making·Douglas Teoh
Feb 23, 2020·Stroke; a Journal of Cerebral Circulation·Jun Young ChangMoon-Ku Han
Apr 3, 2019·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Eva A RochaAneesh B Singhal

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