Lower In-Hospital Ventricular Tachyarrhythmia in Patients With Acute Myocardial Infarction Receiving Prior Statin Therapy

Angiology
Jin Sup ParkKorean Acute Myocardial Infarction Registry-National Institutes of Health Investigators

Abstract

We evaluated whether prior statin therapy reduces in-hospital ventricular tachycardia/ventricular fibrillation (VT/VF) in percutaneous coronary intervention (PCI) patients with acute myocardial infarction (MI). Among the 1177 patients from the Acute Myocardial Infarction Registry-National Institutes of Health (KAMIR-NIH), 823 (70%) patients received prior statin therapy. Prior statin therapy was associated with a reduced risk of VT/VF events in both adjusted propensity score analysis (odds ratio [OR] 0.414, 95% confidence interval [CI], 0.198-0.865, P = .019) and adjusted inverse probability of treatment weight analysis (OR 0.463, 95% CI, 0.216-0.994, P = .048). The risk of in-hospital death did not differ significantly between those with or without prior statin therapy (hazard ratio [HR] 0.416, 95% CI, 0.112-1.548, P = .191). Major adverse cardiac events occurred in 116 (8.9%) patients during follow-up. Prior statin therapy was associated with a lower risk of major adverse cardiac events during the follow-up period (HR 0.486, 95% CI, 0.243-0.974, P = .042); however, this was mainly driven by reduced noncardiac death. Prior statin therapy might reduce the incidence of serious cardiac tachyarrhythmia, such as VT/VF, in patients ...Continue Reading

References

Mar 11, 1993·The New England Journal of Medicine·F ZijlstraH Suryapranata
Aug 24, 2000·Epidemiology·J M RobinsB Brumback
Sep 15, 2000·Journal of the American College of Cardiology·J De SutterG De Backer
Jul 10, 2003·Journal of the American College of Cardiology·L Brent MitchellUNKNOWN AVID Investigators
May 7, 2009·JAMA : the Journal of the American Medical Association·Rajendra H MehtaUNKNOWN APEX AMI Investigators
Aug 20, 2010·American Journal of Therapeutics·Nikolas WanahitaPaul Schweitzer

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Citations

Sep 15, 2018·Angiology·Savas CelebiSinan Aydogdu

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