Lower Left Ventricular Ejection Fraction Relates to Cerebrospinal Fluid Biomarker Evidence of Neurodegeneration in Older Adults.

Journal of Alzheimer's Disease : JAD
Hailey A KresgeAngela L Jefferson

Abstract

Subclinical cardiac dysfunction is associated with decreased cerebral blood flow, placing the aging brain at risk for Alzheimer's disease (AD) pathology and neurodegeneration. This study investigates the association between subclinical cardiac dysfunction, measured by left ventricular ejection fraction (LVEF), and cerebrospinal fluid (CSF) biomarkers of AD and neurodegeneration. Vanderbilt Memory & Aging Project participants free of dementia, stroke, and heart failure (n = 152, 72±6 years, 68% male) underwent echocardiogram to quantify LVEF and lumbar puncture to measure CSF levels of amyloid-β42 (Aβ42), phosphorylated tau (p-tau), and total tau (t-tau). Linear regressions related LVEF to CSF biomarkers, adjusting for age, sex, race/ethnicity, education, Framingham Stroke Risk Profile, cognitive diagnosis, and apolipoprotein E ɛ4 status. Secondary models tested an LVEF x cognitive diagnosis interaction and then stratified by diagnosis (normal cognition (NC), mild cognitive impairment (MCI)). Higher LVEF related to decreased CSF Aβ42 levels (β= -6.50, p = 0.04) reflecting greater cerebral amyloid accumulation, but this counterintuitive result was attenuated after excluding participants with cardiovascular disease and atrial fibr...Continue Reading

References

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Feb 15, 2018·Journal of the American Heart Association·Hailey A KresgeAngela L Jefferson

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Citations

Aug 25, 2020·Clinical and Experimental Hypertension : CHE·Mehmet Ilkin Naharci, Bilal Katipoglu
Aug 2, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Osamu Manabe, Masanao Naya
Feb 12, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Elizabeth E Moore, Angela L Jefferson
Mar 4, 2021·Acta Physiologica·Kewarin JinawongSiriporn C Chattipakorn
Jun 27, 2021·Journal of Neuroscience Methods·Ming XuJing Sui

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