Abstract
To assess the diagnostic value of MRI examination in detecting and monitoring osteonecrotic lesions (ON) in childhood acute lymphoblastic leukaemia (ALL) after chemotherapy (CHT) and/or bone marrow transplantation (BMT). Seventy-three patients (37 males, mean age 12.4 years old) with ALL after treatment underwent a lower-limb MR examination between November 2006 and March 2012. In 47 there was clinical suspicion of ON, 26 were asymptomatic. Studies were performed with a 1 T and a 1.5 T scanner, acquiring short tau inversion recovery (STIR) and T1-weighted sequences in coronal plane from the hips to the ankles. The average acquisition time was 18 min. Considering baseline and follow-up examinations, the overall number of MRI studies was 195. Fifty-four of 73 patients showed ON at MRI study, with an overall number of 323 ON (89 involving articular surface, 24 with joint deformity, JD). Twenty-five of 47 symptomatic patients showed subchondral ON lesions, 11 developed JD. Three of 26 asymptomatic patients showed subchondral bone ON at baseline examination but no JD at follow-up. Twenty-two of 28 BMT, 32/45 CHT patients developed ON. Our MRI protocol proved to be feasible in evaluating ON in paediatric patients. Studies should be a...Continue Reading
References
Jun 17, 1978·Lancet·R ObristJ P Obrecht
Jan 1, 1990·Pediatric Radiology·G Benz-BohmF Berthold
Jan 1, 1985·The Journal of Bone and Joint Surgery. British Volume·R P Ficat
Aug 1, 1988·Radiology·B G ColemanE K Cohen
Jul 1, 1986·AJR. American Journal of Roentgenology·M D MitchellL Axel
Jan 28, 1984·British Medical Journal·P G HarperR L Souhami
Oct 1, 1997·Medical and Pediatric Oncology·A E OjalaB M Lanning
Dec 10, 1999·AJR. American Journal of Roentgenology·M W AndersonP A Kaplan
Sep 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L A MattanoJ B Nachman
Jun 22, 2001·Leukemia·R C RibeiroC H Pui
Dec 18, 2001·British Journal of Cancer·A M CookR A Huddart
Jan 13, 2004·Bone Marrow Transplantation·S C KasteG A Hale
Jan 13, 2006·The New England Journal of Medicine·Ching-Hon Pui, William E Evans
Jan 26, 2006·Bone Marrow Transplantation·J D RizzoG Socié
Dec 16, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Alessandra SalaRonald D Barr
Dec 8, 2007·Pediatric Blood & Cancer·Ronald D Barr, Alessandra Sala
Jan 16, 2008·Clinical Orthopaedics and Related Research·Frederic ZadeganLaurent Sedel
Mar 11, 2008·Clinical Orthopaedics and Related Research·Byung-Woo MinKyung-Jae Lee
May 12, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Mohammad Amin KerachianEdward J Harvey
Jun 26, 2009·The New England Journal of Medicine·Ching-Hon PuiMary V Relling
Sep 8, 2010·Bone Marrow Transplantation·S SharmaS C Kaste
Sep 17, 2010·The Journal of Bone and Joint Surgery. American Volume·Michael A MontRonald E Delanois
Dec 15, 2010·Blood·Jitesh D KawediaMary V Relling
Feb 24, 2011·Current Molecular Medicine·C FanC J Xian
Feb 26, 2011·Blood·James B Nachman
Apr 23, 2011·AJR. American Journal of Roentgenology·Sue C KasteMichael D Neel
Nov 15, 2011·British Journal of Haematology·Ajay Vora
Apr 25, 2012·AJR. American Journal of Roentgenology·Rakhee Kisan SansgiriSue C Kaste