Lower-limb muscle function during gait in varus mal-aligned osteoarthritis patients

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Prasanna SritharanMarcus G Pandy

Abstract

This study quantified the contributions by muscular, gravitational and inertial forces to the ground reaction force (GRF) and external knee adduction moment (EKAM) for knee osteoarthritis (OA) patients and controls walking at similar speeds. Gait data for 39 varus mal-aligned medial knee OA patients and 15 controls were input into musculoskeletal models to calculate the contributions of individual muscles and gravity to the fore-aft (progression), vertical (support), and mediolateral (balance) GRF, and the EKAM. The temporal patterns of contributions to GRF and EKAM were similar between the groups. Magnitude differences in GRF contributions were small but some reached significance. Peak GRF contributions were lower in patients except hamstrings in early-stance progression (p < 0.001) and gastrocnemius in late-stance progression (p < 0.001). Both EKAM peaks were higher in patients, due mainly to greater adduction contribution from gravity (p < 0.001) at the first peak, and lower abduction contributions from soleus (p < 0.001) and gastrocnemius (p < 0.001) at the second peak. Gluteus medius contributed most to EKAM in both groups, but was higher in patients during mid-stance only (p < 0.001). Differences in GRF contributions were...Continue Reading

References

May 1, 1990·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M P KadabaM E Wootten
Mar 1, 1996·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M AndrewsT P Andriacchi
Aug 12, 1998·The Journal of Orthopaedic and Sports Physical Therapy·E M RoosB D Beynnon
Feb 13, 2001·Journal of Biomechanics·F C Anderson, M G Pandy
Jul 13, 2001·JAMA : the Journal of the American Medical Association·L SharmaD D Dunlop
Mar 14, 2003·Gait & Posture·Frank C Anderson, Marcus G Pandy
Dec 1, 1957·Annals of the Rheumatic Diseases·J H KELLGREN, J S LAWRENCE
Nov 30, 2004·Clinical Biomechanics·Tibor HortobágyiPaul DeVita
Sep 1, 2005·Journal of Biomechanics·Kotaro Sasaki, Richard R Neptune
Oct 12, 2005·Journal of Biomechanics·May Q LiuScott L Delp
Nov 21, 2007·IEEE Transactions on Bio-medical Engineering·Scott L DelpDarryl G Thelen
Apr 2, 2008·Medicine and Science in Sports and Exercise·Stephanie C PettersonLynn Snyder-Mackler
Sep 30, 2008·Journal of Biomechanics·May Q LiuScott L Delp
Mar 24, 2009·Journal of Biomechanics·Saryn R Goldberg, Thomas M Kepple
May 11, 2010·Journal of Biomechanics·Marcus G PandyHyung Joo Kim
Jun 1, 2010·Annals of the Rheumatic Diseases·Leena SharmaMichael Nevitt
Jul 14, 2010·Annual Review of Biomedical Engineering·Marcus G Pandy, Thomas P Andriacchi
Aug 13, 2010·Arthritis Care & Research·Rana S HinmanKim L Bennell
May 27, 2011·Computer Methods in Biomechanics and Biomedical Engineering·Tim W DornMarcus G Pandy
Apr 3, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Prasanna SritharanMarcus G Pandy
Apr 24, 2012·Gait & Posture·Tomas A CorreaMarcus G Pandy
Nov 28, 2012·Osteoarthritis and Cartilage·D KumarK S Rudolph
Dec 27, 2012·Gait & Posture·Yoong Ping LimMarcus G Pandy
Jun 13, 2013·The Journal of Orthopaedic and Sports Physical Therapy·Shawn FarrokhiG Kelley Fitzgerald
Dec 17, 2014·Journal of Biomechanics·Yi-Chung LinMarcus G Pandy
Apr 19, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Prasanna SritharanMarcus G Pandy
May 14, 2017·Clinical Biomechanics·Glaucia Helena GonçalvesStela Márcia Mattiello

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