Lower Limb Task-Based Functional Connectivity Is Altered in Stroke

Brain Connectivity
Kaleb VinehoutSheila M Schindler-Ivens

Abstract

The goal of this work was to examine task-dependent functional connectivity of the brain in people with stroke. The work was motivated by prior observations indicating that, during pedaling, cortical activation volume is lower in people with stroke than controls. During paretic foot tapping, activation volume tends to be higher in people with stroke than controls. This study asked whether these differences could be explained by altered network function of the brain. Functional magnetic resonance imaging was used to examine local and global network function of the brain during tapping and pedaling in 15 stroke and 8 control participants. Independent component analysis was used to identify six task regions of interest (ROIs) in the primary sensorimotor cortex (M1S1), anterior lobe of cerebellum (AlCb), and secondary sensory cortex (S2) on the lesioned and non-lesioned sides of the brain (left, right for controls). Global connectivity was calculated as the correlation between mean time series for each ROI. Local connectivity was calculated as the mean correlation between voxels within each ROI. Local efficiency, weighted sum, and clustering coefficient were also calculated. Results suggested that local and global networks of the b...Continue Reading

References

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Methods Mentioned

BETA
Extraction

Software Mentioned

Brain Extraction Tool
Advanced Normalization Tools ( ANTs )
fMRI Expert Analysis Tool
SPSS Statistics
Statistical Package for the Social Sciences
3dDeconvolve in Analysis of Functional NeuroImages
fMRI Brain Software Library

Related Concepts

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Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.