Lower liver transplant success in females: gender differences in metabolic response to global ischemia

Transplantation Proceedings
C WittnichW J Wallen

Abstract

Research has shown that gender plays a significant role in the metabolic processes of different organs and that transplanting livers of females into male or female recipients has significantly higher failure rates. To understand why, this study examined whether gender differences exist in various metabolic responses of livers to ischemia. The following metabolic liver parameters in Sprague-Dawley rats (male, n = 14; and female, n = 18) were examined; adenosine triphosphate (ATP) and lactate expressed as micromoles/g dry weight, and hydrogen ion content [H+] expressed as 10(-8) mol/L. In vivo liver biopsy specimens were compared with ischemic biopsy specimens at 3, 10, 15, 30, and 45 minutes (37 degrees C). In vivo female ATP values (9.9 +/- 0.8) were similar to males (9.8 +/- 0.9) and both had early, rapid decline during ischemia reaching 20% of baseline by 10 minutes of ischemia. In contrast, male liver lactate accumulation peaked by 3 minutes and at much lower levels (35 +/- 13), whereas female liver lactate peaked by 10 minutes at 71 +/- 11. For the rest of the ischemic period, female livers exhibited significantly (P < .05) greater lactate accumulation. Female liver H+ levels also increased to higher levels (55 +/- 10) than...Continue Reading

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References

Dec 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I R MarinoT E Starzl
Aug 1, 1996·Mayo Clinic Proceedings·C T Wass, W L Lanier
Dec 27, 1996·Transplantation·B K BrooksG B Klintmalm
May 1, 1997·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M WatanabeS Kobayashi
Jan 8, 1999·The Journal of Surgical Research·P DutkowskiT Junginger
Sep 11, 1999·The American Journal of Cardiology·P Théroux
May 25, 2002·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Michael P BelangerCarin Wittnich

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Citations

May 7, 2010·Current Opinion in Organ Transplantation·Ayse AytamanNorah A Terrault
Jun 15, 2011·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Chuan LiYong-Gang Wei
Aug 5, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Frank LehnerJürgen Borlak
Nov 23, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Patrizia BurraErica Villa
Oct 15, 2013·Journal of Hepato-biliary-pancreatic Sciences·Kristopher P CroomeNatasha Chandok
Apr 19, 2016·The Journal of Clinical Investigation·David D AufhauserMatthew H Levine
Jul 27, 2017·European Journal of Gastroenterology & Hepatology·Christos TriantosKonstantinos Thomopoulos
Sep 26, 2007·Transplantation·Stjepan SoricCarin Wittnich
Oct 5, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Lee S NguyenShaida Varnous
Sep 16, 2018·Scientific Reports·Christos TriantosKonstantinos Thomopoulos

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