Lower mortality in geriatric patients receiving risperidone and olanzapine versus haloperidol: preliminary analysis of retrospective data

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
Henry A NasrallahAmelia T Nasrallah

Abstract

The authors examined the mortality rate in geriatric patients receiving either haloperidol or atypical antipsychotics. Authors tracked mortality over a 2-year period in patients age 65 years or older receiving haloperidol (N=299) or the atypical antipsychotics risperidone or olanzapine (N= 1,254). Sixty-four patients in the haloperidol group (21.4%) and 61 patients in the atypical group (4.75%) died during the 2-year study period. The difference was statistically significant. The findings suggest that mortality in elderly patients receiving haloperidol is significantly higher than in those receiving the atypical antipsychotics risperidone or olanzapine. Authors discuss possible causal mechanisms.

Citations

Jul 20, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dilip V JesteKristine Yaffe
Dec 3, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Nathan Herrmann, Serge Gauthier
Oct 24, 2006·The Australian and New Zealand Journal of Psychiatry·Jean HollisLoelle Forrester

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