Abstract
The protein Klotho is involved in biological processes related to longevity, cardiovascular health, and cognition. Serum Klotho levels have been associated with better cognition in animal models; moreover, lower Klotho concentrations in cerebrospinal fluid from subjects with late-onset Alzheimer's disease (LOAD) have been reported. Our study aimed to examine the possible relationship between Klotho plasma concentrations and cognitive status in the elderly. We evaluated plasma Klotho levels in a sample of 320 elderly patients admitted to a Memory Clinic. Four groups of subjects were enrolled, including cognitively intact individuals complaining about memory loss (controls) and patients affected by LOAD, mild cognitive impairment, or vascular dementia (VD). The sample was stratified by plasma Klotho tertiles. Lower levels of plasma Klotho (1st tertile) were associated with older age, higher prevalence of VD, single/multiple lacunar infarcts and leukoaraiosis, coronary heart disease and stroke, and higher levels of creatinine, homocysteine, and high-sensitivity C-reactive protein. On multivariate logistic regression analysis, the risk of VD was 3- and 4-fold in subjects belonging to the 1st tertile (≤514.8 pg/mL, OR 3.54, 95% CI 1...Continue Reading
References
Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jul 1, 1984·Neurology·G McKhannE M Stadlan
Feb 1, 1993·Neurology·G C RománA Hofman
Nov 18, 1997·Nature·M Kuro-oY I Nabeshima
Feb 17, 1998·Biochemical and Biophysical Research Communications·Y MatsumuraY Nabeshima
Apr 16, 1998·FEBS Letters·T Shiraki-IidaY Nabeshima
Jul 24, 1998·Biochemical and Biophysical Research Communications·Y SaitoR Nagai
Jul 13, 2000·Cellular and Molecular Life Sciences : CMLS·R NagaiM Kuroo
Dec 26, 2001·Archives of Neurology·R C PetersenB Winblad
Apr 6, 2002·Stroke; a Journal of Cerebral Circulation·J C de la Torre
Jun 1, 2002·Ageing Research Reviews·Lenore J Launer
Sep 7, 2002·Stroke; a Journal of Cerebral Circulation·Donald R Royall
Feb 26, 2004·Lancet Neurology·Jack C de la Torre
May 12, 2004·FEBS Letters·Akihiro ImuraYo-Ichi Nabeshima
Aug 27, 2005·Science·Hiroshi KurosuMakoto Kuro-o
Jan 27, 2006·The Journal of Biological Chemistry·Hiroshi KurosuMakoto Kuro-o
Apr 8, 2006·Journal of Psychiatric Research·G ZulianiR Fellin
Nov 7, 2006·Nature·Itaru UrakawaTakeyoshi Yamashita
Jun 16, 2007·Science·Akihiro ImuraYo-ichi Nabeshima
Jul 2, 2011·Journal of the American Society of Nephrology : JASN·Juan A MorenoAna B Sanz
Feb 23, 2013·PloS One·Masashi KitagawaHirofumi Makino
Mar 8, 2013·Seminars in Nephrology·Ming Chang HuOrson W Moe
Oct 30, 2013·Heart·Juan F Navarro-GonzálezCarmen Mora-Fernández
Nov 12, 2013·Neuroscience Letters·Richard D SembaRichard O'Brien
May 13, 2014·Cell Reports·Dena B DubalLennart Mucke
Aug 21, 2015·The Tohoku Journal of Experimental Medicine·Nursen KelesAytekin Oguz
Aug 25, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Michelle ShardellLuigi Ferrucci
Sep 26, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jonas Mengel-FromLene Christiansen
Dec 3, 2015·World Journal of Biological Chemistry·Javier Donate-CorreaJuan F Navarro-González
Jun 16, 2016·Dementia and Geriatric Cognitive Disorders·Veronica TisatoGiovanni Zuliani
May 26, 2017·Maturitas·Osvaldo P AlmeidaLeon Flicker
Jun 15, 2017·JAMA Cardiology·Kiran Musunuru
Citations
May 10, 2019·Annals of Medicine·Jun-Beom LeeTae-Jin Song
Aug 10, 2019·PloS One·Ho Geol WooTae-Jin Song
Jun 12, 2019·International Journal of Molecular Sciences·Virginia CipolliniFranco Giubilei
Jan 8, 2020·International Journal of Molecular Sciences·Donato GemmatiTiziana Bellini
Feb 5, 2021·The Journal of Applied Laboratory Medicine·Jean-Sébastien PaquetteMathieu Pelletier
Feb 3, 2021·Molecular Neurobiology·Xiang GaoRena Li
Sep 10, 2020·Archives of Gerontology and Geriatrics·Yasemin PolatMurat Varli
Apr 3, 2021·AJOB Neuroscience·Veljko DubljevićRobert Ranisch
Nov 2, 2021·Frontiers in Psychiatry·Xiang GaoRena Li