Lower Plasma Klotho Concentrations Are Associated with Vascular Dementia but Not Late-Onset Alzheimer's Disease

Gerontology
Gloria BromboGiovanni Zuliani

Abstract

The protein Klotho is involved in biological processes related to longevity, cardiovascular health, and cognition. Serum Klotho levels have been associated with better cognition in animal models; moreover, lower Klotho concentrations in cerebrospinal fluid from subjects with late-onset Alzheimer's disease (LOAD) have been reported. Our study aimed to examine the possible relationship between Klotho plasma concentrations and cognitive status in the elderly. We evaluated plasma Klotho levels in a sample of 320 elderly patients admitted to a Memory Clinic. Four groups of subjects were enrolled, including cognitively intact individuals complaining about memory loss (controls) and patients affected by LOAD, mild cognitive impairment, or vascular dementia (VD). The sample was stratified by plasma Klotho tertiles. Lower levels of plasma Klotho (1st tertile) were associated with older age, higher prevalence of VD, single/multiple lacunar infarcts and leukoaraiosis, coronary heart disease and stroke, and higher levels of creatinine, homocysteine, and high-sensitivity C-reactive protein. On multivariate logistic regression analysis, the risk of VD was 3- and 4-fold in subjects belonging to the 1st tertile (≤514.8 pg/mL, OR 3.54, 95% CI 1...Continue Reading

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Citations

Jun 12, 2019·International Journal of Molecular Sciences·Virginia CipolliniFranco Giubilei
Feb 5, 2021·The Journal of Applied Laboratory Medicine·Jean-Sébastien PaquetteMathieu Pelletier
Sep 10, 2020·Archives of Gerontology and Geriatrics·Yasemin PolatMurat Varli
Apr 3, 2021·AJOB Neuroscience·Veljko DubljevićRobert Ranisch

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