Lower prefrontal gray matter volume in schizophrenia in chronic but not in first episode schizophrenia patients

Psychiatry Research
Vicente MolinaTomás Palomo

Abstract

Although a lower volume of prefrontal (PF) gray matter (GM) in patients with schizophrenia than in normal control subjects is a replicated finding, it is not yet clear whether this finding is present at the onset of illness. Clinical and imaging data suggest that the reduction in PF GM becomes apparent only some years following the onset of illness. To test this hypothesis, we used magnetic resonance imaging to study PF GM and sulcal cerebrospinal fluid (CSF) volumes in 81 schizophrenic patients. A Talairach-based tool was used for segmentation. Subjects included 44 healthy controls, 22 first-episode (FE), treatment-naïve patients with duration of illness of less than 1 year; 29 short-term chronic (SC) patients with durations of illness between 1.5 and 6 years; and 30 long-term chronic (LC) patients with duration of illness of more than 6 years. The data from healthy controls were used to calculate volume residuals in the patients, defined as deviations from the expected values given individual age and intracranial volume. The FE group did not show significant differences in GM or in CSF volumes compared with controls. However, both the SC and the LC patients showed the expected pattern of lower values for PF GM and an excess o...Continue Reading

References

Dec 1, 1992·Alcoholism, Clinical and Experimental Research·A PfefferbaumE V Sullivan
Oct 1, 1994·The American Journal of Psychiatry·R M BilderJ A Lieberman
Mar 1, 1994·The American Journal of Psychiatry·R E GurR C Gur
Jan 1, 1996·Journal of Computer Assisted Tomography·N C AndreasenW T Yuh
Feb 1, 1997·Psychiatry and Clinical Neurosciences·T OhnumaH Arai
Nov 5, 1997·NeuroImage·J Ashburner, K Friston
Jun 20, 1998·Archives of General Psychiatry·R B ZipurskyD J Mikulis
May 13, 1999·Psychiatry Research·P R SzeszkoJ A Lieberman
Jun 22, 2000·NeuroImage·J Ashburner, K J Friston
Aug 2, 2000·Archives of General Psychiatry·R E GurR C Gur
Nov 4, 2000·The American Journal of Psychiatry·D FannonT Sharma
Mar 21, 2001·Biological Psychiatry·J LiebermanR Bilder
Apr 3, 2001·The American Journal of Psychiatry·A R GilbertM S Keshavan
Oct 3, 2001·The British Journal of Psychiatry : the Journal of Mental Science·R M NormanA K Malla
Sep 26, 2002·The British Journal of Psychiatry. Supplement·Eileen JoyceThomas Barnes
Nov 7, 2002·Archives of General Psychiatry·Wiepke CahnRené S Kahn
Dec 31, 2002·The American Journal of Psychiatry·Beng-Choon HoNancy C Andreasen

❮ Previous
Next ❯

Citations

Sep 12, 2012·Schizophrenia Research and Treatment·Borah KimYoung-Chul Chung
May 9, 2007·Archives of General Psychiatry·Dean F SalisburyRobert W McCarley
Dec 1, 2009·The Psychiatric Clinics of North America·Arman Danielyan, Henry A Nasrallah
Sep 1, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Luisa TomelleriUNKNOWN Neuroimaging Network of the ECNP networks initiative
Oct 4, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·H KleinlogelS Begré
Oct 2, 2007·European Psychiatry : the Journal of the Association of European Psychiatrists·V MolinaM Desco
Dec 22, 2007·NeuroImage·Anna Rotarska-JagielaDavid E J Linden
Jul 25, 2014·Human Psychopharmacology·Takefumi SuzukiMasaru Mimura
Jan 3, 2006·Psychiatry Research·Katherine L NarrArthur W Toga
Aug 6, 2015·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Lan-Ting LeeYen Kuang Yang
Jul 11, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Müge Devrim-UçokAlp Uçok
Aug 2, 2005·Psychiatry Research·Thomas J WhitfordLeanne M Williams
Jul 5, 2005·Biological Psychiatry·Erin A HazlettMonte S Buchsbaum
Apr 2, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mohamed AhmedColm McDonald
Jan 1, 2011·Schizophrenia Research and Treatment·Victor Vostrikov, Natalya Uranova
Oct 4, 2007·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·S Begré, T Koenig
Apr 28, 2005·Expert Review of Neurotherapeutics·Preethi Premkumar, Tonmoy Sharma
Feb 2, 2010·The Australian and New Zealand Journal of Psychiatry·Faruk UguzRengin Karatayli
Sep 13, 2005·European Archives of Psychiatry and Clinical Neuroscience·Vicente MolinaTomás Palomo
Mar 3, 2007·The British Journal of Psychiatry : the Journal of Mental Science·Philip R SzeszkoRobert M Bilder
Feb 27, 2008·Brain : a Journal of Neurology·Yong LiuTianzi Jiang

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.