Lower rates of cardiovascular events and mortality associated with liraglutide use in patients treated with basal insulin: A DEVOTE subanalysis (DEVOTE 10)

Diabetes, Obesity & Metabolism
Kirstine Brown-FrandsenDEVOTE Study Group

Abstract

To compare the associations between concomitant liraglutide use versus no liraglutide use and the risk of major adverse cardiovascular events (MACE) and all-cause mortality among patients receiving basal insulin (either insulin degludec [degludec] or insulin glargine 100 units/mL [glargine U100]) in the Trial Comparing Cardiovascular Safety of Insulin Degludec versus Insulin Glargine in Patients with Type 2 Diabetes at High Risk of Cardiovascular Events (DEVOTE). Patients with type 2 diabetes and high cardiovascular risk were randomized 1:1 to degludec or glargine U100. Hazard ratios for MACE/mortality were calculated using a Cox regression model adjusted for treatment and time-varying liraglutide use at any time during the trial, without interaction. Sensitivity analyses were adjusted for baseline covariates including, but not limited to, age, sex, smoking and prior cardiovascular disease. At baseline, 436/7637 (5.7%) patients were treated with liraglutide; after baseline, 187/7637 (2.4%) started and 210/7637 (2.7%) stopped liraglutide. Mean liraglutide exposure from randomization was 530.2 days. Liraglutide use versus no liraglutide use was associated with significantly lower hazard rates for MACE [0.62 (0.41; 0.92)95%CI ] an...Continue Reading

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Citations

Jul 10, 2019·Diabetes, Obesity & Metabolism·Cees J TackUNKNOWN LEADER Publication Committee on behalf of the LEADER Trial Investigators
Jan 25, 2020·Clinical Diabetes : a Publication of the American Diabetes Association·Mark Warren, Donna Steel

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Clinical Trials Mentioned

NCT01959529

Software Mentioned

DEVOTE
LEADER

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CV Disorders & Type 2 Diabetes

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