PMID: 18209912Jan 23, 2008Paper

Lower respiratory tract infection caused by respiratory syncytial virus in infants: the role played by specific antibodies

Clinics
Sandra E VieiraBernardo Ejzenberg

Abstract

Respiratory syncytial virus (RSV) is a major etiological agent of lower respiratory tract infection in infants. Genotypes of this virus and the role of the infants' serum antibodies have yet to be fully clarified. This knowledge is important for the development of effective therapeutic and prophylactic measures. To evaluate the types and genotypes of RSV causing respiratory tract infection in infants, to analyze the association of subtype-specific serum antibodies with the occurrence of infection and to evaluate the presence of subtype-specific antibodies in the infants' mothers and their association with the profile of the childrens' serum antibodies. This was a prospective study on infants hospitalized with respiratory infection. Nasopharyngeal secretions were collected for viral investigation using indirect immunofluorescence and viral culture and blood was collected to test for antibodies using the Luminex Multiplex system. 192 infants were evaluated, with 60.9% having RSV (73.5%- A and 20.5% B). Six genotypes of the virus were identified: A5, A2, B3, B5, A7 and B4. The seroprevalence of the subtype-specific serum antibodies was high. The presence and levels of subtype-specific antibodies were similar, irrespective of the p...Continue Reading

Citations

Nov 15, 2013·Reviews in Medical Virology·Jop JansGerben Ferwerda
Apr 11, 2019·Frontiers in Immunology·Elisabeth A van ErpPuck B van Kasteren
Aug 15, 2014·Revista paulista de pediatria : orgão oficial da Sociedade de Pediatria de São Paulo·Ana Isabel M P MonteiroLily Yin Weckx
Oct 31, 2009·Memórias do Instituto Oswaldo Cruz·Marcos AmakuFrancisco Antonio Bezerra Coutinho

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