Lower respiratory tract infection induced by a genetically modified picornavirus in its natural murine host.

PloS One
Louis A RosenthalRonald L Sorkness

Abstract

Infections with the picornavirus, human rhinovirus (HRV), are a major cause of wheezing illnesses and asthma exacerbations. In developing a murine model of picornaviral airway infection, we noted the absence of murine rhinoviruses and that mice are not natural hosts for HRV. The picornavirus, mengovirus, induces lethal systemic infections in its natural murine hosts, but small genetic differences can profoundly affect picornaviral tropism and virulence. We demonstrate that inhalation of a genetically attenuated mengovirus, vMC(0), induces lower respiratory tract infections in mice. After intranasal vMC(0) inoculation, lung viral titers increased, peaking at 24 h postinoculation with viral shedding persisting for 5 days, whereas HRV-A01a lung viral titers decreased and were undetectable 24 h after intranasal inoculation. Inhalation of vMC(0), but not vehicle or UV-inactivated vMC(0), induced an acute respiratory illness, with body weight loss and lower airway inflammation, characterized by increased numbers of airway neutrophils and lymphocytes and elevated pulmonary expression of neutrophil chemoattractant CXCR2 ligands (CXCL1, CXCL2, CXCL5) and interleukin-17A. Mice inoculated with vMC(0), compared with those inoculated with v...Continue Reading

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Citations

Feb 29, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Rakesh K KumarPaul S Foster
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Jul 13, 2021·Clinical & Translational Immunology·Jean-Francois Lauzon-JosetDeborah H Strickland

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Methods Mentioned

BETA
transgenic
bronchoalveolar lavage
ELISA
enzyme-linked immunosorbent assay
Protein Assay

Software Mentioned

SYSTAT

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